本研究は、若齢期の超低周波(ELF)磁界ばく露が認知機能に及ぼす影響を調べた動物実験である。23-35日齢の雄のアルビノKunming系マウスを、2mTの50Hz磁界に60分/日ばく露した。36-45日齢時に、磁界ばく露が空間記憶の課題遂行能力に及ぼす潜在的影響を、Y字型迷路およびモーリス式水迷路で調べた。その結果、本研究の実験条件下では、磁界ばく露はY字型迷路の課題遂行能力に影響しなかった;水迷路での空間学習の獲得と記憶維持が向上した、と報告している。
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In the present study early adolescent mice were used as a model to investigate the potential effects of chronic exposure to extremely low frequency magnetic field during this developmental stage on some aspects of cognitive function.
16 mice were exposed from postnatal days 23-35 to a 50 Hz magnetic field for 60 min/day. On postnatal days 36-45, the potential effects of the magnetic field exposure on spatial memory performance were examined. 17 mice were sham exposed. Only 22 mice (n=11 each group) were used in the Morris water maze task.
ばく露 | パラメータ |
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ばく露1:
50 Hz
ばく露時間:
continuous for 60 min/day from postnatal days 23 to 35
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|
周波数 | 50 Hz |
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タイプ |
|
波形 |
|
ばく露時間 | continuous for 60 min/day from postnatal days 23 to 35 |
ばく露の発生源/構造 | |
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ばく露装置の詳細 | 70 cm x 40 cm x 43 cm plastic frame was wrapped with 4 horizontal layers with 250 turns each, forming a single coil with a 60 cm x 30 cm x 43 cm exposure area inside; mice placed in a 50 cm x 25 cm x 25 cm plastic box in this exposure area; field variation inside the plastic box: ± 4.5 %; exposure system placed in a room with a constant temperature of 30°C |
Sham exposure | A sham exposure was conducted. |
測定量 | 値 | Method |
---|---|---|
磁束密度 | 2 mT | 測定値 |
The data showed that the magnetic field exposure did not affect Y-maze performance, but improved spatial learning acquisition and memory retention in the Morris water maze task (exposed mice learned to locate the platform faster than sham-exposed mice).
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