この研究は、ニューロン様細胞(レチノイン酸誘導によりヒト神経芽細胞腫SH-SY5Y細胞を分化させたもの)に対する1800MHzマイクロ波ばく露(2時間または4時間)の影響を調べた。その結果、細胞の生育能力、Hsp27発現、カスパーゼ-3活性に有意な変化は認められなかった;どちらのばく露時間でもHsp20発現の有意な低下が認められたが、Hsp70のレベルは4時間ばく露のみで有意に上昇した、などの所見を報告している。
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To study the effects of radiofrequency exposure on the stress response in neuroblastoma cells, differentiated to dopaminergic neuron-like cells (induced by retinoic acid).
周波数 | 1,760 MHz |
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タイプ |
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ばく露時間 | continuous for 2 h and 4 h |
ばく露の発生源/構造 |
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Distance between exposed object and exposure source | 3 cm |
Sham exposure | A sham exposure was conducted. |
Additional information | no increase of temperature was measured around the cultures during exposure |
Under these experimental conditions, neither apoptosis nor Hsp27 expression nor caspase 3 expression were significantly changed following exposure. However, a significant decrease in Hsp20 expression was found at both times of exposure (2 and 4 h), whereas Hsp70 levels were significantly increased only after 4 h exposure (according to the abstract; within the results section, the authors also demonstrate a significant increase after the 2 h exposure compared with the sham exposed cells, remark EMF-Portal). Additionally, p-Hsp27 (phosphorylated Hsp27) expression was significantly increased in the exposed cells compared with the controls.
Remark EMF-Portal: The data on the cell viability are not clearly documented according to significance (in the abstract and discussion section: no change; within the results section: decrease), c.f. full text link.
The changes in the expression of the heat shock proteins in neuronal cells could be an early response to the microwave exposure.
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