To study the effects of radiofrequency exposure on the stress response in neuroblastoma cells, differentiated to dopaminergic neuron-like cells (induced by retinoic acid).
Exposure | Parameters |
---|---|
Exposure 1:
1,760 MHz
Exposure duration:
continuous for 2 h and 4 h
|
|
Frequency | 1,760 MHz |
---|---|
Type | |
Exposure duration | continuous for 2 h and 4 h |
Exposure source |
|
---|---|
Distance between exposed object and exposure source | 3 cm |
Sham exposure | A sham exposure was conducted. |
Additional info | no increase of temperature was measured around the cultures during exposure |
Measurand | Value | Type | Method | Mass | Remarks |
---|---|---|---|---|---|
SAR | 0.086 W/kg | - | calculated | - | average |
electric field strength | 25 V/m | maximum | measured | - | - |
magnetic field strength | 66 mA/m | maximum | measured | - | - |
power density | 1.7 W/m² | maximum | measured | - | - |
Under these experimental conditions, neither apoptosis nor Hsp27 expression nor caspase 3 expression were significantly changed following exposure. However, a significant decrease in Hsp20 expression was found at both times of exposure (2 and 4 h), whereas Hsp70 levels were significantly increased only after 4 h exposure (according to the abstract; within the results section, the authors also demonstrate a significant increase after the 2 h exposure compared with the sham exposed cells, remark EMF-Portal). Additionally, p-Hsp27 (phosphorylated Hsp27) expression was significantly increased in the exposed cells compared with the controls.
Remark EMF-Portal: The data on the cell viability are not clearly documented according to significance (in the abstract and discussion section: no change; within the results section: decrease), c.f. full text link.
The changes in the expression of the heat shock proteins in neuronal cells could be an early response to the microwave exposure.
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