Studientyp:
Medizinische/biologische Studie
(experimentelle Studie)
Proto-oncogene mRNA levels and activities of multiple transcription factors in C3H 10T 1/2 murine embryonic fibroblasts exposed to 835.62 and 847.74 MHz cellular phone communication frequency radiation
med./bio.
[Proto-Onkogen mRNA-Gehalte und Aktivitäten mehrerer Transkriptionsfaktoren in C3H 10T1/2 Mausembryo-Fibroblasten, die bei 835.62 und 847.74 MHz Handy-Kommunikations-Frequenzen exponiert wurden]
A detailed description of the radial transmission line (RTL) and a temperature-controlled facility containing nine RTLs has been given in the reference articles. The RTL is a shielded irradiator consisting of a parallel-plate region (43 mm spacing, total radius of 533 mm) with the bottom aluminium plate acting as a thermal homogenizer for the flasks. A central conical antenna (203 mm in diameter) emitted TEM waves radially outward that were terminated by RF-absorbing material backed by a lamina of perforated aluminium.
Aufbau
A total of 16 T-75 culture flasks each containing 40 ml of medium could be distributed angularly around the antenna. The cell layer in the flasks was subjected to a perpendicular EF and a circumferential MF perpendicular to the EF and the direction of propagation inducing a radial component to the EF.
Sham exposures were performed in an identical RTL without the RF field. The temperature of the culture medium was maintained at 37.0 ± 0.25°C by feedback controllers for each RTL.
Moros EG et al.
(1999):
The radial transmission line as a broad-band shielded exposure system for microwave irradiation of large numbers of culture flasks
Moros EG et al.
(1999):
Compact shielded exposure system for the simultaneous long-term UHF irradiation of forty small mammals. II. Dosimetry
National Institutes of Health (NIH), Maryland, USA
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Whitehead TD et al.
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Expression of the proto-oncogene Fos after exposure to radiofrequency radiation relevant to wireless communications
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Analysis of proto-oncogene and heat-shock protein gene expression in human derived cell-lines exposed in vitro to an intermittent 1.9 GHz pulse-modulated radiofrequency field
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