研究のタイプ: 医学／生物学の研究 (experimental study)

[エチルニトロソ尿素マウスモデルにおけるUMTS変調無線周波電磁界慢性ばく露の共発がん性の兆候] med./bio.

Indication of cocarcinogenic potential of chronic UMTS-modulated radiofrequency exposure in an ethylnitrosourea mouse model

著者: Tillmann T, Ernst H, Streckert J, Zhou Y, Taugner F, Hansen V, Dasenbrock C
掲載誌: Int J Radiat Biol 2010; 86 (7): 529-541
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この研究は、マウスの腫瘍感受性に対するUMTS信号ばく露の影響、およびエチルニトロソ尿素（ENU)との共発がん性について調べた（ばく露は胚・胎児期に開始し、最大24ヶ月間継続）。動物を擬似ばく露群（0 W/m2）、低ばく露群（4.8 W/m2）、高ばく露群（48 W/m2）に分け、低ばく露群は出生前にENU（40 mg /kg 体重）投与を行った。その結果、高ばく露群・擬似ばく露群・ケージ対照群の腫瘍発生率は同等であった；それとは対照的に、ENU処置の低ばく露群ではENU処置のみの群に比べ、肺での腫瘍の発症率と上皮性がん腫の発症率が高くなり、肺での腫瘍の多様性と転移性腫瘍の数が増えた、などの知見を報告している。

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研究目的（著者による）

To study the tumour susceptibility in mice exposed to a UMTS signal for up to 24 months commencing with embryo-fetal exposure.

詳細情報

Animals were exposed to UMTS electromagnetic fields with different intensities (4.8 and 48 W/m²) and the low-dose group (4.8 W/m²) was additionally subjected to prenatal ethylnitrosourea treatment (40 mg ENU/kg body weight).
In total, five treatment groups were used: Two exposure groups, sham exposure group, cage control group and positive control group (ENU treatment only). Exposure and sham exposure of the maternal mice started on day 6 post conception, while the maternal ENU treatment was carried out on day 14 post conception. Each treatment group consisted originally of up to 20 maternal mice and their litters. After the first week of lifetime, litter standardisation was performed and afterwards three female offspring per cage and their mothers were maintained up to the weaning time point. After weaning, maternal mice were removed from the cages and the study was conducted using the three remaining female offspring (thus about 60 mice per group).
Different pre-studies were also performed (e.g. concerning thermoregulation or ENU mortality of a different mouse strain).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,966 MHz
ばく露時間: continuous for 20 hr/day, 7 days/week for up to 24 months
  • 電力密度: 4.8 W/m² average over time (deck with low exposure)
  • 電力密度: 48 W/m² average over time (deck with high exposure)
  • SAR: 0.62 W/kg average over mass (whole body) (3 pups (3 g, together with the dam))
  • SAR: 1.19 W/kg average over mass (whole body) (3 old females (55 g))
  • SAR: 3.84 W/kg average over mass (whole body) (1 mature female (30 g))
  • SAR: 4.48 W/kg average over mass (whole body) (1 mature female (30 g, together with 3 pups))
  • SAR: 5.76 W/kg average over mass (whole body) (3 young females (12.5 g))

General information

animals were treated in five groups: i) cage control - no treatment ii) ENU control 40 mg ENU per kg body weight iii) sham exposure iv) UMTS exposure to 4.8 W/m² + 40 mg ENU per kg body weight v) UMTS exposure to 48 W/m²

ばく露1

主たる特性
周波数 1,966 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 20 hr/day, 7 days/week for up to 24 months
ばく露装置
ばく露の発生源／構造
チャンバの詳細 exposure performed in a three decker exposure device (sham, low and high exposure; see exposure parameters)
ばく露装置の詳細 test signal delivered by a generic UMTS signal generator and amplified with a power amplifier
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 4.8 W/m² average over time - - deck with low exposure
電力密度 48 W/m² average over time - - deck with high exposure
SAR 0.62 W/kg average over mass 計算値 whole body 3 pups (3 g, together with the dam)
SAR 1.19 W/kg average over mass 計算値 whole body 3 old females (55 g)
SAR 3.84 W/kg average over mass 計算値 whole body 1 mature female (30 g)
SAR 4.48 W/kg average over mass 計算値 whole body 1 mature female (30 g, together with 3 pups)
SAR 5.76 W/kg average over mass 計算値 whole body 3 young females (12.5 g)

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

The high-level UMTS exposure (48 W/m²), the sham exposure, and the cage control groups showed comparable tumour incidences in the organs. In contrast, the ENU-treated and UMTS-co-exposed (at 4.8 W/m²) animals displayed an enhanced lung tumour rate and an increased incidence of lung carcinomas as compared to the controls treated with ENU only. Furthermore, tumour multiplicity of the lung carcinomas was increased and the number of metastasising lung tumours was doubled in the ENU/UMTS co-exposure group as compared to the ENU control group.
The authors conclude that this pilot study indicates a cocarcinogenic effect of lifelong UMTS exposure (4.8 W/m²) in female B6C3F1 offspring subjected to pretreatment with ethylnitrosourea.

研究の種別:

研究助成

Replication studies

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