研究のタイプ: 医学／生物学の研究 (experimental study)

[Sprague-Dawley雌ラットの生存に対するGSM様信号（携帯電話）慢性ばく露の影響：誕生月および太陽活動周期による調節作用の可能性] med./bio.

Effect of chronic exposure to a GSM-like signal (mobile phone) on survival of female Sprague-Dawley rats: Modulatory effects by month of birth and possibly stage of the solar cycle

著者: Bartsch H, Küpper H, Scheurlen U, Deerberg F, Seebald E, Dietz K, Mecke D, Probst H, Stehle T, Bartsch C
掲載誌: Neuro Endocrinol Lett 2010; 31 (4): 457-473
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低レベルGSM様信号（900MHzの217Hzパルス、平均電力密度100μW/cm2、全身平均SAR38～80mW/kg）への慢性ばく露による非拘束のSprague-Dawley雌ラットの健康と生存への影響について、同一条件下での長期実験を著者らはこれまでに4件行った。今回の論文はその総合的分析である。1997～2000年の2件の長期ばく露実験（実験I、II）は、ばく露・擬似ばく露群各12匹で、無線周波（RF）ばく露を、52～70日齢から開始し、それぞれ24ヵ月（実験I）、17ヵ月（実験II）継続し、それぞれ770日齢、580日齢まで観察した。その結果、実験I、II とも肉眼的および顕微鏡的検査によって慢性RFばく露による健康影響を検出しなかった；観察終了時に50%以上が生存していたため、生存期間中央値は推定できなかった、と述べている。実験III（2002～2005年）、IV（2005～2008年）は、ばく露・擬似ばく露群各30匹で、同じく52～70日齢からRFばく露を開始し、生涯ばく露を継続し、それぞれ36、37ヵ月間観察した（自然死または瀕死時の安楽死まで）。実験III、IVの生存データを分析した結果、両実験ともばく露群での生存期間中央値が有意に減少した（9.06%）；実験IVに比べ実験IIIでは、ばく露・擬似ばく露の両群とも生存期間中央値が減少した（6.25%、有意性なし）；実験IIIのラットは10月生まれ、実験IVのラットは5月生まれという事実が関係するかも知れない、と報告している。

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研究目的（著者による）

To study the effect of chronic exposure to a low intensity GSM-like signal on health and survival of unrestrained female rats kept under identical conditions.

詳細情報

During 1997-2008 two long-term (experiments I and II) and two life-long (experiments III and IV) experiments were performed. In the first two experiments (1997-2000) 12 exposed and 12 sham exposed rats (each experiment) were observed until all surviving rats were sacrificed at 25 (770 days; experiment I) or 19 months of age (580 days; experiment II). In the course of two survival experiments (experiments III and IV: 2002-2005 and 2005-2008) 30 exposed and 30 sham exposed animals (each experiment) were followed up until their natural end or when they became moribund and had to be euthanized (maximal survival time was 36-37 months).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: continuous (except times for feeding, cleaning, health inspection, etc.): 24 months (exp. I), 17 (exp. II), 36 (exp. III), and 37 (exp. IV) months
  • 電力密度: 100 µW/cm² mean (cage bottom)
  • SAR: 80 mW/kg mean (whole body) (animals 2 months old)
  • SAR: 44 mW/kg mean (whole body) (animals 4-6 months old)
  • SAR: 38 mW/kg mean (whole body) (animals 11-12 months old)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • far field
偏波
  • circular
ばく露時間 continuous (except times for feeding, cleaning, health inspection, etc.): 24 months (exp. I), 17 (exp. II), 36 (exp. III), and 37 (exp. IV) months
Modulation
Modulation type pulsed
Pulse width 577 µs
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源／構造
  • flat spiral antenna
チャンバの詳細 exposure chambers were placed in two adjacent rooms (no windows) of equal dimensions (RF exposure and sham exposure); no mobile communication possible within the rooms; 12 hours light (28-35 lux) per 24 hours; detailed description of an identical exposure set-up (identical parameters and intensity) in Bartsch H. et al. (2002)
ばく露装置の詳細 12 unrestrained animals per cage, located within exposure chamber or sham chamber
Sham exposure A sham exposure was conducted.
Additional information exposure began with 52 (I), 53 (II) , 70 (III) or 63 (IV) days of age depending on experiment group; animals sacrificed at 25 (I) and 19 (II) months of age; groups III and IV observed until natural end
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 100 µW/cm² mean - - cage bottom
SAR 80 mW/kg mean 計算値 whole body animals 2 months old
SAR 44 mW/kg mean 計算値 whole body animals 4-6 months old
SAR 38 mW/kg mean 計算値 whole body animals 11-12 months old

Reference articles

  • Bartsch H et al. (2002): [GSM様信号（携帯電話）への慢性ばく露は、ラットのDMBA誘発乳腺腫瘍の成長を刺激しない：３つの連続研究の結果]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

In experiment I no adverse health effects of chronic exposure were detectable, neither by macroscopic nor microscopic pathological examinations. Also in experiment II no apparent macroscopic pathological changes due to irradiation were found.
Median survival was significantly shortened under exposure in experiments III and IV by 9.06%, i.e by 72 days in experiment III and 77 days in experiment IV as compared to the sham exposed rats. Both groups of animals of experiment III showed reduced median survival times by 6.25% compared to the corresponding groups of experiment IV which may be due to the fact that animals of experiment III were born in October and animals of experiment IV in May indicating that the month of birth affects life span.
From the data of the last two experiments it has to be concluded that chronic exposure to a low intensity GSM-like signal may exert negative health effects and shorten survival if treatment is applied sufficiently long and the observational period covers the full life span of the animals concerned. The data show that survival of rats kept under controlled laboratory conditions varies within certain limits depending on the month of birth. To further prove these complex interactions and processes it is necessary to systematically continue the experiments.

研究の種別:

研究助成

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