研究のタイプ: 医学／生物学の研究 (experimental study)

[SD雌ラットでのDMBA誘発乳腺腫瘍に対するGSM900マイクロ波の影響] med./bio.

Effects of GSM-900 microwaves on DMBA-induced mammary gland tumors in female Sprague-Dawley rats

著者: Anane R, Dulou PE, Taxile M, Geffard M, Crespeau FL, Veyret B
掲載誌: Radiat Res 2003; 160 (4): 492-497
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この研究は、GSM900マイクロ波への亜慢性全身ばく露が、腫瘍のプロモーション、プログレッションに影響するか否かを調べた。SD雌ラットに7,12-ジメチルベンズアントラセン（DMBA) 10mgを1回投与し、乳腺腫瘍を誘発させた。2つの独立した実験を、それぞれ4群（各群16匹；擬似ばく露群、3つのばく露群）で行った。第1回実験は、5月－7月に、全身平均SAR3.5、2.2、1.4W/kgで、第2回実験は、9月－11月に、同1.4、0.7、0.1W/kgで行った。ばく露は、DMBA処置から10日後に開始、1日2時間、1週間に5日、9週間継続した。ばく露した電磁界は、電界成分の向きがラットの体軸と平行な平面波である。体重、腫瘍の数、位置、大きさを定期観察し、ばく露終了から3週間後に屠殺して、病理検索した。その結果、ばく露は、腫瘍の潜伏期、多発性、腫瘍体積に影響しなかった；腫瘍発症率については、第1回実験でのみ、1.4W/kgで上昇が見られたが、2.24W/kgでは上昇は小さく、3.5W/kgでは見られなかった、と報告している。

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研究目的（著者による）

(1) To test the hypothesis that sub-chronic whole-body exposure to GSM (global system for mobile communication) 900 microwaves had an effect on tumor promotion and tumor progression and (2) to look for a threshold for the effect in the SAR range from 0.1 to 3.5 W/kg.

詳細情報

Mammary tumors were induced by ingestion of a single dose of 7,12-dimethylbenzanthracene (DMBA, 10 mg) in female rats.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure, 2 h/day, 5 days/week for 9 weeks
  • SAR: 3.5 W/kg spatial average (whole body)
  • SAR: 2.2 W/kg spatial average (whole body)
  • SAR: 1.4 W/kg spatial average (whole body) (Experiment 1 + 2)
  • SAR: 0.7 W/kg spatial average (whole body)
  • SAR: 0.1 W/kg spatial average (whole body)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 repeated daily exposure, 2 h/day, 5 days/week for 9 weeks
Additional information plane wave
Modulation
Modulation type pulsed
ばく露装置
ばく露の発生源／構造
Distance between exposed object and exposure source 1.8 m
チャンバの詳細 Two identical anechoic chambers (3 m x 3 m x 3 m) were used, one with a base station antenna above the cages and another one for sham exposure.
ばく露装置の詳細 The animal cages of Plexiglas were divided into 20 separate compartments (6 cm x 6 cm x 17 cm) in two rows that kept the animals parallel to the electric field. Gel phantoms were placed in the 4 outermost compartments in order to provide uniform exposure for the 16 rats.
Additional information In each of the two experiments, the rats were divided into five groups: three groups exposed at different levels, one sham-exposed group, and another untreated cage control group.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 3.5 W/kg spatial average 測定値 whole body -
SAR 2.2 W/kg spatial average 測定値 whole body -
SAR 1.4 W/kg spatial average 測定値 whole body Experiment 1 + 2
SAR 0.7 W/kg spatial average 測定値 whole body -
SAR 0.1 W/kg spatial average 測定値 whole body -
Additional parameter details

SAR values have been averaged over the compartments and the rat's body.

測定および計算の詳細

The SAR was measured using polyacrylamide gel phantom rats and thermistor probes. The SAR was determined at a specific location in the head of one phantom placed in each compartment in turn, with the other compartments also occupied, and at 11 locations within the phantom in one of the compartments. More energy was absorbed at the top of the phantom than at the bottom.

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • mammary gland
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

The findings are negative in terms of latency, multiplicity and tumor volume. With regard to tumor incidence, there was an increase in the rate of incidence at 1.4 W/kg but less at 2.2 W/kg and none at 3.5 W/kg. A trend toward a reduction of malignant tumor incidence and multiplicity was found at the lowest SAR level with a concomitant increase in benign tumor multiplicity.
Overall, these data, which are rather inconsistent, do not bring new evidence of a co-promoting effect of exposure to GSM-900 signals using the DMBA rat model.

研究の種別:

研究助成

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