研究のタイプ: 医学／生物学の研究 (experimental study)

[ラットの卵胞の変化に対する非電離電磁界の影響] med./bio.

Effect of non-ionizing electromagnetic field on the alteration of ovarian follicles in rats

著者: Ahmadi SS, Khaki AA, Ainehchi N, Alihemmati A, Khatooni AA, Khaki A, Asghari A
掲載誌: Electron Physician 2016; 8 (3): 2168-2174
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この研究は、ラットに50Hz磁界ばく露を2通りのばく露期間で与え、ばく露終了後に摘出された卵胞標本を、対照群の標本と比較した。ばく露は、8週間ばく露（子宮内で3週間、出生後5週間）、13週間ばく露（子宮内で3週間、出生後10週間）である。2つのばく露群および対照群はそれぞれn=10であった。その結果、ばく露が卵胞の形態学的変化を引き起こし、卵母細胞の分化および卵胞形成に影響を与えた、と報告している。（JEIC注：一定数の雌新生仔を得たプロセスや母ラットに関する説明、またばく露装置に関する説明は論文中に全くなく、ばく露パラメータ、ばく露方法は不明である。結果も顕微鏡像観察の記述のみである。）

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研究目的（著者による）

The effects of exposure of rats to a 50 Hz or 60 Hz magnetic field on the histology of ovarian follicles should be investigated.

詳細情報

30 three-month old rats were divided into 3 groups (n=10 each): 1) exposure for 8 weeks (three weeks intrauterine and five weeks ectopic (?)), 2) exposure for 13 weeks (three weeks intrauterine and ten weeks ectopic (?)), 3) non-exposed control group.
(remark EMF-Portal: The exposure conditions and the experimental design are not clear. The three-month old rats were probably pregnant and their offspring was exposed and investigated.)

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50–60 Hz
ばく露時間: for 8 weeks (3 weeks intrauterine + 5 weeks ectopic)
-
ばく露2: 50–60 Hz
ばく露時間: for 13 weeks (3 weeks intrauterine + 10 weeks ectopic)
-

ばく露1

主たる特性
周波数 50–60 Hz
タイプ
  • magnetic field
ばく露時間 for 8 weeks (3 weeks intrauterine + 5 weeks ectopic)
Additional information contradictory statements on frequency (50 Hz or 50 Hz - 60 Hz)
ばく露装置
ばく露の発生源／構造
  • 詳細不明
パラメータ

No parameters are specified for this exposure.

ばく露2

主たる特性
周波数 50–60 Hz
タイプ
  • magnetic field
ばく露時間 for 13 weeks (3 weeks intrauterine + 10 weeks ectopic)
Additional information contradictory statements on frequency (50 Hz or 50 Hz - 60 Hz)
ばく露装置
ばく露の発生源／構造
  • 詳細不明
パラメータ

No parameters are specified for this exposure.

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

In the control group (group 3), the thickness of the zona pellucida and the Theca layer were regular.
In group 1 (8 week exposure), the thickness of the zona pellucida and the Theca layer were irregular in some parts.
In group 2 (13 week exposure), disappearance and destruction of granulosa of the growing primary follicles and irregular oocytes in the follicle were observed. Additionally, the structure of the ovarian stroma was disrupted and accumulation of collagen fibers in the form of fibrosis was observed in parts of the stroma.
The atresia (i.e. breakdown) of the ovarian follicles was significantly different (not further specified) in both exposure groups compared to the control group.
The authors conclude that exposure of rats to a 50 Hz or 60 Hz magnetic field might affect the histology of ovarian follicles.

研究の種別:

研究助成

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