この研究は、発電所で高い電磁界に職業ばく露された男性労働者77人および年齢でマッチングした低ばく露の労働者77人について、血漿ホルモン性および炎症性の経路のバイオマーカーに対する電磁界ばく露の影響を評価した。社会人口統計学的特徴、生活様式、電磁界ばく露についての関連情報はアンケートで得た。テストステロン、エストラジオール、メラトニン、NF-κB、熱ショックタンパク質（HSP）70、HSP27、TET1の血漿レベルは酵素免疫測定法（ELISA）で判定した。その結果、ばく露群は対照群と比較して、テストステロン（β=-0.3nmol/L、P=0.015）、テストステロン／エストラジオール（T/E）比（β=-15.6、P=0.037）、NF-κB（β=-20.8ng/L、P=0.045）が統計的に有意に低かった。更に、テストステロンのレベルおよびT/E比に対する、電磁界への職業ばく露と雇用期間、携帯電話料金、携帯電話の使用年数、電気料金との連合効果が認められた。但し、電磁界ばく露とエストラジオール、メラトニン、HS70、HSP27、TET1の血漿レベルとの統計的に有意な関連は認められなかった。著者らは、これらの知見は、電磁界への慢性ばく露は男性の血漿テストステロンおよびT/E比を低下させる可能性があり、それによって生殖機能に影響を及ぼすかも知れないことを示している、と結論付けている。
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A case-control study was conducted in China to evaluate the effects of occupational exposure to electromagnetic fields on levels of plasma hormones and inflammatory pathway biomarkers in male workers of a power plant.
The results on serum lipids investigated in a subgroup of same study population were published by Wang et al (2015).
A blood sample was taken from each participant to analyze hormone and biomarker levels.
Remark EMF-Portal: The classification into 'low occupational EMF exposure' and 'high occupational EMF exposure' is not clear.
| グループ | 説明 |
|---|---|
| 参照集団 1 | low occupational exposure: no walkie-talkies use, daily exposure < 4 h, employment duration < 15 years |
| 集団 2 | high occupational exposure: walkie-talkies use, daily exposure ≥ 4 h, employment duration ≥ 15 years |
| 参照集団 3 | low occupational exposure, employment duration: < 23 years |
| 集団 4 | low occupational exposure, employment duration: ≥ 23 years |
| 集団 5 | high occupational exposure, employment duration: < 23 years |
| 集団 6 | high occupational exposure, employment duration: ≥ 23 years |
| 参照集団 7 | low occupational exposure, daily duration: ≤ 4 hours/day |
| 集団 8 | low occupational exposure, daily duration: > 4 hours/day |
| 集団 9 | high occupational exposure, daily duration: ≤ 4 hours/day |
| 集団 10 | high occupational exposure, daily duration: > 4 hours/day |
| 参照集団 11 | low occupational exposure and mobile phone use: ≤ 12 years |
| 集団 12 | low occupational exposure and mobile phone use: > 12 years |
| 集団 13 | high occupational exposure and mobile phone use: ≤ 12 years |
| 集団 14 | high occupational exposure and mobile phone use: > 12 years |
| 参照集団 15 | low occupational exposure and mobile phone fee: < 60 yuan/month |
| 集団 16 | low occupational exposure and mobile phone fee: ≥ 60 yuan/month |
| 集団 17 | high occupational exposure and mobile phone fee: < 60 yuan/month |
| 集団 18 | high occupational exposure and mobile phone fee: ≥ 60 yuan/month |
| 参照集団 19 | low occupational exposure and monthly electric fee: ≤ 150 yuan/month |
| 集団 20 | low occupational exposure and monthly electric fee: > 150 yuan/month |
| 集団 21 | high occupational exposure and monthly electric fee: ≤ 150 yuan/month |
| 集団 22 | high occupational exposure and monthly electric fee: > 150 yuan/month |
| タイプ | 値 |
|---|---|
| 合計 | 2,138 |
| 参加者 | 747 |
| 評価可能 | 154 |
The average measured intensity of occupational exposure was 316.3±1212.3 V/m for electric field and 6.17±14.71 µT for magnetic fields in high exposure group, which far outstripped that in low exposure group (3.9±0.3 V/m and 60.6±16.9 nT, respectively).
Significantly lower levels of testosterone and NF-KB and a significantly reduced testosterone/estradiol ratio were observed in workers with higher occupational exposure (group 2) in comparison to the reference group 1. No significant associations were found for estradiol, melatonin, or for the inflammatory pathway biomarkers HSP70, HSP27, or TET1. High exposure groups with longer employment duration, longer mobile phone use, higher mobile phone fee or higher electric fee per month showed lower levels of testosterone and testosterone/estradiol ratio compared to the respective reference groups.
The authors concluded that chronic exposure to electromagnetic fields could decrease male plasma testosterone and testosterone/estradiol ratio.
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