この研究は、雌の仔ラットの脊髄および運動行動に対する900MHz電磁界への出生前ばく露の影響を調査した。妊娠した雌のSprague-Dawleyラットを対照群およびばく露群に分けた（各n=3）。ばく露群は900MHz電磁界に1時間／日、妊娠13日目から21日目までばく露した。21日齢の時点で、仔ラットを母親から離し、対照群（n=13）およびばく露群（n=10）に分けた。仔ラットの運動機能をロータロッド試験で、自発運動活性をオープンフィールド試験で評価した。生後32日目に仔ラットを断頭し、上部胸郭から脊髄を摘出し、通常の組織学的検査を実施後、クレシルファストバイオレットで染色した。ロータロッド試験の結果、ばく露群の仔ラットの運動機能に有意な増加（p=0.037）が認められたが、オープンフィールド試験では差は認められなかった（p>0.05）。ばく露群の仔ラットでは、脊髄の組織学的変化が認められた。著者らはこの結果から、900MHz電磁界への出生前ばく露は脊髄の形態学的変化の形で脊髄の発達に影響を及ぼし、これは仔ラットの自発運動活性の上昇につながるかも知れない、と結論付けている。
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The effects of prenatal exposure of female rats to a 900 MHz electromagnetic field on spinal cord morphology and motor activity in young rats should be investigated.
Pregnant rats were either exposed or not exposed (n=3, respectively). When rat pups were 21 days old, female pups from non-exposed mothers were assigned to the control group (n=13) and pups from exposed mothers were assigned to the exposure group (n=10). At the age of 26 days, motor activity tests were conducted and at the age of 32 days, rats were killed and histological examinations were conducted.
| 周波数 | 900 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | intermittent for 1 hour/day from day 13 to 21 of pregnancy |
| ばく露の発生源／構造 | |
|---|---|
| チャンバの詳細 | plexiglass jar of 30 cm x 42 cm x 52 cm |
| ばく露装置の詳細 | half-wave dipole antenna made from a copper rod (1 mm x 15 cm) was inserted into the central area of the jar, approximately 11 cm inside the open surface of the jar |
| Additional information | exposure and control groups were maintained in separate cages in the same room during the experiment, except during exposure to EMF, which took place in the EMF exposure room |
Motor coordination and balance were significantly increased in exposed rats compared to the control group, while motor activity did not show any significant differences between the groups.
No pathologic changes were found in spinal cord samples from control rats, while exposed rats showed atrophy, vacuolization in gray matter and occasional myelin thickening, white matter infiltration among the nerve fibers and infiltration of gray matter inside white matter as well as structural impairment in motor neuron cell body structure.
The authors conclude that prenatal exposure of female rats to a 900 MHz electromagnetic field might affect spinal cord morphology which might cause a change in motor functions in young rats.
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