この研究は、ラットの熱性けいれんの潜時、持続時間、および脳波（EEG）記録に対する磁界（MF）ばく露の影響を調べた。ラットは6群（各群n=6）に分けた：擬似ばく露（S）群、熱性けいれん（FC）群、MFばく露（MF）群、MF+FC群、FC+MF群、MF+FC+MF群（処置順に表記）。熱性けいれん誘発後に、直腸温、潜時、持続時間、および脳波を測定した。その結果、繰り返しの高温ばく露により、発作の潜時と持続時間は減少した；MFばく露は、潜時よりも持続時間の減少により大きく影響した；一方、10または12日間のMFばく露は発作潜時を増加させた；MFばく露により、シータ波、デルタ波の増加、ベータ波の減少が見られた､と報告している。
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The effects of exposure of rats to a 50 Hz magnetic field on latency and duration of febrile (=fever) convulsions and the EEG should be investigated.
36 rats were randomly divided into the following groups: 1) no febrile convulsion inductions and sham exposure, 2) febrile convulsion inductions and sham exposure, 3) exposure to magnetic field without febrile convulsion inductions, 4) daily exposure to magnetic field before febrile convulsion inductions, 5) daily exposure to magnetic field after febrile convulsion inductions, 6) daily exposure to magnetic field before and after ffebrile convulsion inductions.
All rats were operatively equipped with electrodes placed directly on the dura mater (the outermost membrane of the meninges) for recording of the EEG. Exposure to the magnetic field and inductions of febrile convulsions started 22 days after the surgery and were conducted for a period of 20 days. Febrile convulsions were induced every second day (total of 10 seizures) by placing the animals of febrile convulsion groups in water with a temperature of 45°C, whereas groups without febrile convulsion were placed in water with 37°C. Depending on the group, this was done before (group 4) or after (group 5) exposure of the respective day or in the meantime (group 6) (remark EMF-Portal: no further information in the article).
| 周波数 | 50 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | intermittent for 30 minutes every 15 minutes for 540 minutes/day for 20 days (remark EMF-Portal: specifications in the article are unclear) |
| ばく露の発生源／構造 | |
|---|---|
| チャンバの詳細 | plexiglas cage (40 Œ 17 Œ 13 cm) |
| ばく露装置の詳細 | solenoid was 500 mm in length and 210 mm in diameter, was made of 1400 turns of an insulated soft copper wire with 1.4 mm in diameter and was placed on a fiber base; it was always kept in a north-south direction and its temperature was maintained at 25 ± 2°C |
| Sham exposure | A sham exposure was conducted. |
| Additional information | all devices that could affect the magnetic field were kept away from the experimental area |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 5 mT | - | 測定値および計算値 | - | - |
The rectal temperature was significantly higher after a febrile seizure than before in all groups with febrile convulsion inductions (2, 4, 5, 6).
The latency duration of seizures was significantly increased in all febrile convulsion groups exposed to a magnetic field (groups 4, 5, 6) compared to group 2 (febrile convulsion inductions without exposure) after 10 and 12 days of exposure.
The seizure duration was significantly higher in group 2 after 2 days of exposure until the end of the experiment compared to groups 4, 5, 6.
The power of alpha waves was significantly increased and the power of beta waves, which were characterized as physiological waves of the waking state, significantly decreased in groups 2-6 compared to group 1 (no febrile convulsion inductions and sham exposure). The power of theta waves and delta waves, which were characterized as pathological waves, was significantly increased in groups 4, 5 and 6 compared to group 1.
The authors conclude that exposure of rats to a 50 Hz magnetic field might decrease the duration of febrile convulsions but could also have a negative effect on brain waves.
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