この研究は、マウスを用いた実験で、50 Hz、0.1 mTの磁界（MF）への急性、亜急性、および長期ばく露がけいれん発作誘発閾値に及ぼす影響を調べた。64匹のマウスを4群（n = 16）に分け、1日（急性）、3日（亜急性）、2週間（亜急性）、1ヶ月（長期）実験群とした。各実験群において、任意の8匹は擬似ばく露群として用い、残りの8匹はそれぞれのばく露期間で磁界ばく露を受けた。どのばく露期間の場合も、1日のばく露時間は2時間とした。ばく露期間終了後、けいれん発作を誘発するためのペンチレンテトラゾール（PTZ）を注射して、発作誘発閾値の用量を測定した。その結果、急性ばく露では、ばく露群と擬似ばく露群における発作誘発閾値はそれぞれ44.25mgと46.5mgで、その差は有意でなかった；亜急性ばく露では、発作誘発閾値の平均は、ばく露群47.38 mg、擬似ばく露群43.88 mgで有意差はなかった；2週間ばく露の場合、同じく52.38と46.75mgで有意差もなかった；1か月ばく露群では、発作誘発閾値は有意に増加し、ばく露群54.3mg、擬似ばく露群45.75mgであった；総括すると、磁界ばく露時間は発作誘発閾値を増加させることが示された、と報告している。
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64 mice were divided into four groups (8 mice were sham exposed and 8 mice were magnetic field exposed per group): 1.) exposure/sham exposure for 1 day, 2.) exposure/sham exposure for 3 days, 3.) exposure/sham exposure for 2 weeks and 4.) exposure/sham exposure for 1 month. After exposure/sham exposure, pentylenetetrazol was injected into the mice. The injected dose needed to induce a seizure was measured.
No significant differences were found between mice that were magnetic field exposed or sham exposed for 1 day, 3 days and 2 weeks. However, in mice exposed to a magnetic field for 1 month, the dose of pentylenetetrazol needed to induce a seizure was significantly higher compared to mice that were sham exposed for 1 month.
The authors conclude that long-term exposure to extremely low frequency magnetic fields could increase the seizure induction threshold in mice.
