研究のタイプ: 医学／生物学の研究 (experimental study)

[血小板凝集に対する50 Hz磁界の影響に関する血液凝集計による研究] med./bio.

Investigation of the effects of 50 Hz magnetic fields on platelet aggregation using a modified aggregometer

著者: Sagdilek E, Sebik O, Celebi G
掲載誌: Electromagn Biol Med 2012; 31 (4): 382-393
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この研究は、血小板凝集に対する50 Hzの磁界（1mT×1.5時間または6 mT×1時間）の影響を80人の健常者から採血した血液について調べた。採血後に用いた抗凝固剤によりヘパリン群、クエン酸ナトリウム群を作成し、それぞれに処理を行って多血小板血漿（PRP）を採集し、それらに磁界ばく露を行い、凝集パラメータを対照群と比較した。その結果、クエン酸ナトリウム群の1 mT ばく露群でのみ、コラーゲン誘導性の凝集曲線における立ち上りの最初のスロープ（凝集速度）および最大凝集率に有意な増加がみられた、と報告している。

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研究目的（著者による）

To study whether 50 Hz magnetic fields (1 mT and 6 mT) have any effects on platelet aggregation.

詳細情報

Blood from 80 healthy volunteers was anti-coagulated with either sodium citrate or heparin (n=40 each). Each sample was divided in an exposed and a sham exposed sample. Adenosine diphosphate, collagen, and epinephrine were used as aggregation inducing agents. 60 samples (30 sodium citrate, 30 heparin) were exposed at 1 mT, 20 samples were exposed at 6 mT (10 sodium citrate, 10 heparin).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 1.5 h
  • 磁束密度: 1 mT (± 0.05 mT (at the center of the coils))
ばく露2: 50 Hz
ばく露時間: continuous for 1 h
  • 磁束密度: 6 mT (± 0.05 mT (at the center of the coils))

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 1.5 h
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 two coils were connected in series; coils were built using a 2 mm copper wire wound on a circular frame of 50 cm diameter (350 turns in each coil)
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
磁束密度 1 mT - 測定値 - ± 0.05 mT (at the center of the coils)
Additional parameter details

The average temperature changes between the beginning and the end of the experiment were 0.1°C for the 1 mT exposure group and 0.2°C for the control group.
Ambient magnetic field intensities were 0.05-0.15 mT (for direct current) and 0.12-0.21 mT (for alternative current).

ばく露2

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 1 h
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
磁束密度 6 mT - - - ± 0.05 mT (at the center of the coils)
Additional parameter details

The average temperature changes between the beginning and the end of the experiment were 2°C for the 6 mT exposure group and 0.2°C for the control group. Heating of the samples was the reason why exposure duration was limited to 1 h.
Ambient magnetic field intensities were 0.05-0.15 mT (for direct current) and 0.12-0.21 mT (for alternative current).

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

Exposure to a 1 mT 50 Hz magnetic field for 1.5 h had a significant effect on the aggregation parameters of collagen-induced aggregation in sodium citrate treated samples: the maximum values and slope of the collagen-induced aggregation curve were significantly increased. No significant differences were found in any other group.

研究の種別:

研究助成

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