この研究は、健康なボランティア(n=83)の唾液中のサイトカイン発現プロファイルをELISA 法で測定し、そのデータと携帯電話使用に関する自己申告データとの相関を調べた。その結果、携帯電話使用と反対側の耳下腺からの唾液に比較した同側耳下腺からの唾液のサイトカインIL-10減少およびIL-1β増加が有意であった;このような両側でのIL-10の差異は、使用年数10年以上のボランティアで大きかった;月間の使用時間(分単位)との相関は何ら観察されなかった、と報告している。
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The effects of mobile phone usage on inflammatory cytokine expression in the saliva produced by the parotid glands should be investigated.
Saliva samples from both parotid glands were collected from 83 healthy volunteer students (1 subject was excluded from analysis) and the cytokine expression profile was correlated with the self-reported mobile phone use. Self-reported parameters for usage were: cumulative monthly cell phone use (up to 200 min (n=48) or more than 200 minutes (n=34)), period of cell phone use (up to 10 years (n=47) or more than 10 years (n=35)) and laterality of use (right (n=75) or left ear (n=7)).
ばく露 | パラメータ |
---|---|
ばく露1:
ばく露時間:
up to 200 minutes per month for up to 10 years
|
- |
ばく露2:
ばく露時間:
up to 200 minutes per month for more than 10 years
|
- |
ばく露3:
ばく露時間:
more than 200 minutes per month for up to 10 years
|
- |
ばく露4:
ばく露時間:
more than 200 minutes per month for more than 10 years
|
- |
Protein expression of interleukin-10 was significantly decreased and protein expression of interleukin-1β and the total protein concentration were significantly increased in samples from the ipsilateral parotid gland (i.e., from the head side of prefered mobile usage) compared to the contralateral gland. Subjects who used mobile phones for more than 10 years presented a significantly higher decrease in interleukin-10 levels in the ipsilateral samples compared to ipsilateral samples from subjects who used their mobile phone for up to 10 years.
All other parameters did not show any significant correlations with the mobile phone usage.
The authors conclude that mobile phone usage might increase the expression of inflammatory cytokines interleukin-1β and interleukin-10 in the saliva produced by the ipsilateral parotid gland. The causes for these effects are unknown but may be related to heat production.
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