研究のタイプ: 医学／生物学の研究 (experimental study)

[脳組織のマイクロRNA発現に対するWi-Fi機器から放射される2.4GHzの無線周波放射の影響] med./bio.

Effects of 2.4 GHz radiofrequency radiation emitted from Wi-Fi equipment on microRNA expression in brain tissue

著者: Dasdag S, Akdag MZ, Erdal ME, Erdal N, Ay OI, Ay ME, Yilmaz SG, Tasdelen B, Yegin K
掲載誌: Int J Radiat Biol 2015; 91 (7): 555-561
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この研究は、Wistarアルビノ雄ラット（ばく露群、擬似ばく露群それぞれn=8）の脳組織のマイクロRNA（miRNAs）発現に対するWi-Fi機器の2.4GHz電磁界の1日24時間、1年間ばく露の影響を調べた。擬似ばく露群ではWi-Fi機器をオフにした。ばく露終了後直ちに脳標本を作製し、miR-9-5p、miR-29a-3p、miR-106b-5p、miR-107、miR-125a-3pを調べた。その結果、ばく露群では、一部のmiRNAsの発現に変化が見られた、と報告している。

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研究目的（著者による）

The effects of a chronic exposure of rats to a 2.4 GHz electromagnetic field (WLAN) on the expression rates of some microRNAs in the brain should be investigated.

詳細情報

MicroRNAs are small, non-coding RNA molecules, which play an important role in growth, differentiation, proliferation and cell death by influencing the gene expression in cells.
Rats were divided in 2 groups (n=8 each): 1) exposure and 2) sham exposure.
All measurements were conducted in triplicates.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.4 GHz
ばく露時間: continuous for 24 hours/day for 12 months
  • 電力: 100 mW peak
  • 電力: 50 mW effective value
  • SAR: 4,000 µW/kg peak
  • SAR: 1,510 µW/kg average over mass (1 g)
  • SAR: 1,030 µW/kg average over mass (10 g)
  • SAR: 141.4 µW/kg effective value (whole body)
  • SAR: 7,127 µW/kg maximum (whole body)

ばく露1

主たる特性
周波数 2.4 GHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 continuous for 24 hours/day for 12 months
Additional information WiFi or WLAN signal
ばく露装置
ばく露の発生源／構造
Distance between exposed object and exposure source 50 cm
チャンバの詳細 plexiglass cage (55 x 32 x 20 cm)
ばく露装置の詳細 rats could move freely in cage; WLAN signal generator was connected to a tuned half-wavelength dipole antenna positioned in front of a reflector plate to direct the signal to the cage; a temperature of 22°C and a relative humidity of 45% were maintained; cage was surrounded with electromagnetic absorber material backed by metal to isolate outdoor electromagnetic fields
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
電力 100 mW peak - - -
電力 50 mW effective value - - -
SAR 4,000 µW/kg peak 計算値 - -
SAR 1,510 µW/kg average over mass 計算値 1 g -
SAR 1,030 µW/kg average over mass 計算値 10 g -
SAR 141.4 µW/kg effective value 計算値 whole body -
SAR 7,127 µW/kg maximum 計算値 whole body -

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

The expression rates of rno-miR-106b-5p and rno-miR-107 were significantly decreased in the exposure group in comparison to the sham exposure group.
The authors conclude that a chronic exposure of rats to a 2.4 GHz electromagnetic field (WLAN) could influence the expression rates of some microRNAs in the brain with possibly adverse consequences for the brain.

研究の種別:

研究助成

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