研究のタイプ: 医学／生物学の研究 (experimental study)

[長期かつ過度の900 MHz無線周波放射の使用は脳内のマイクロRNA発現を変化させる] med./bio.

Long term and excessive use of 900 MHz radiofrequency radiation alter microRNA expression in brain

著者: Dasdag S, Akdag MZ, Erdal ME, Erdal N, Ay OI, Ay ME, Yilmaz SG, Tasdelen B, Yegin K
掲載誌: Int J Radiat Biol 2015; 91 (4): 306-311
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この研究は、ウィスターアルビノ雄ラット（n=14）の脳組織のマイクロRNA（miRNAs）に対する900MHz携帯電話電磁界（RF）の長期ばく露の影響を調べた。ばく露群、擬似ばく露群（各群n=7）に、900MHzのばく露（または擬似ばく露）を1日3時間、週7日、12ヶ月間与えた。全身平均SARは0.0369W/kg。ばく露終了直後に脳組織のmiRNAs（rno-miR-9-5p、rno-miR-29a-3p、rno-miR-106b-5p、rno-miR-107、rno-miR-125a-3p）を測定した。その結果、調べたmiRNAsのうちrno-miR107のみがばく露群で有意に低下した；その他のmiRNAsには変化がなかった、と報告している。

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研究目的（著者による）

The effects of a chronic exposure of rats to a 900 MHz electromagnetic field on the expression of some microRNAs in the brain should be investigated.

詳細情報

MicroRNAs are small, non-coding RNA molecules, which play a critical role in gene regulation and could be related to the development of cancer and neurodegenerative diseases.
14 rats were divided into two groups (n=7 each): exposure and sham exposure.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: continuous for 3 h/day on 7 days/week for 12 months
  • SAR: 0.198 W/kg peak (in brain)
  • SAR: 0.143 W/kg mean (1 g) (in brain)
  • SAR: 0.114 W/kg mean (10 g) (in brain)
  • SAR: 0.0369 W/kg effective value (whole body)
  • SAR: 2.023 W/kg maximum (whole body) (± 0.121 W/kg)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 3 h/day on 7 days/week for 12 months
ばく露装置
ばく露の発生源／構造
  • GSM generator + mobile phone antenna equivalent
Distance between exposed object and exposure source 1 cm
チャンバの詳細 rats were confined in a Plexiglas carousel with the antenna in the center; carousel was surrounded by electromagnetic absorber material backed by metal for isolation from environmental electromagnetic fields
ばく露装置の詳細 distance from the antenna to the head of the rats was 1 cm; signal was emitted omnidirectional on the plane perpendicular to the antenna axis; temperature was maintained at 22°C and the relative humidity was maintained at 45%
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 0.198 W/kg peak 測定値および計算値 - in brain
SAR 0.143 W/kg mean 測定値および計算値 1 g in brain
SAR 0.114 W/kg mean 測定値および計算値 10 g in brain
SAR 0.0369 W/kg effective value 測定値および計算値 whole body -
SAR 2.023 W/kg maximum 測定値および計算値 whole body ± 0.121 W/kg

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

The expression rate of rno-miR-107 was significantly reduced in the exposure group compared to sham exposure. The expression rates of the other investigated microRNAs were not significantly different in the two groups.
The authors conclude that a chronic exposure of rats to a 900 MHz electromagnetic field could influence the expression of some microRNAs in the brain.

研究の種別:

研究助成

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