[移植した悪性黒色腫細胞の成長は特定の空間・時間的j構成の低強度磁界への全身ばく露によって抑制される] med./bio.

To measure the effect of exposure to a specific spatial-temporal electromagnetic field presented using different geometric configurations on the growth of experimental tumors in mice.

A total of 65 male mice were used. The experiment was performed in two separate blocks separated by six months to control for potential effects of the endogenous geomagnetic field: Block 1 contained 32 mice and block 2 contained 33 mice. Beginning on the day of cancer cell injection, the mice were exposed to two control (sham exposure and cage control) and six different magnetic field configurations (six groups of four mice) between 21 h and midnight (3 h) every day for 38 days.

• 動物
• mouse/C57b (bearing subcutaneously B16-BL6 melanoma cells in the right hind flank)
• 全身

Mice exposed to the field that was rotated through the three spatial dimensions and through all three planes every two seconds (see field 6) did not grow tumors after 38 days. However, the animals in the sham exposed field and cage controls showed massive tumors after 38 days. Tumor growth was also affected by the intensity of the field, with mice exposed to a weak intensity field (1-5 nT, field 4) forming smaller tumors than animals exposed to sham exposure or high intensity (2-5 µT) fields. The mice exposed to the cylindrical field, Helmholtz field, attenuated geomagnetic field, high intensity field, or the sham exposure conditions formed large tumours that were not different from the non-handled cage controls.
Immunohistochemistry of tumors from those mice exposed to the different intensity fields suggested that alterations in leukocyte infiltration or vascularization could contribute to the differences in tumor growth.
The authors conclude that exposure to specific spatial-temporal regulated electromagnetic field configurations had potent effects on the growth of experimental tumors in mice. These effects were also dependent on the intensity and special complexity of the field pattern.