この研究は、てんかん患者の突然死が部分的に地磁気活動に関連するという仮説を前提に、磁気嵐急始(SSCs)をシミュレートして実験的に生成された磁界に辺縁てんかん誘発ラットをばく露させる実験を行なった。ラットを用いた先行研究では、てんかん誘発ラット群での突然死に、前夜のSSCsの発生および地磁気活動増加が関連することが示されたが、シュナベルら[(2000)Neurology 54:903–908]は、ヒト患者での突然死と地磁気活動の間に関連がないことを示した。今回の実験では、合計96匹のラットが、3夜連続して深夜から朝8時までの間、1時間に6分間、500、50、10〜40 nTまたは擬似(10 nT未満)の磁界ばく露を受けた。複雑に振幅変調された磁界の波形は平均的なSSCの波形と構成をシミュレートした。次に、ラットにリチウムおよびピロカルピンを用いててんかん発作を起こさせ、死亡率を測定した。その結果、擬似ばく露群での24時間以内の死亡率は10 %であったのに対し、SSCsシミュレート磁界ばく露群では60 %で、有意差があった(P <.001)、と報告している。
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To test the hypothesis that sudden unexplained death in some epileptic patients is related to geomagnetic field activity the authors exposed rats in which limbic epilepsy had been induced to experimentally produced magnetic fields designed to simulate sudden storm commencements (SSCs).
Rats were seized with lithium and pilocarpine and the mortality was monitored.
Previous studies with rats had shown that sudden death in groups of rats in which epilepsy had been induced months earlier was associated with the occurrence of SSCs and increased geomagnetic activity during the previous night. Schnabel et al. (see publication 12465) found no relationship between sudden unexplained death in human patients and geomagnetic activity.
周波数 | 7 Hz |
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タイプ |
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ばく露時間 | intermittent, 6 min/hour for 8 hours/night on three consecutive nights |
Modulation type | AM |
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Additional information |
Square waves were amplitude modulated in 14 sequential steps with the duration of each plateau being 14 s and 7 s during the first 3 min and 20 s and the last 1 min and 42 s, respectively. |
ばく露の発生源/構造 | |
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チャンバの詳細 | 4 plastic cages (3 rats/cage) 32 cm x 32 cm x 45 cm with two of them completely surrounded with Helmholtz coils. The long axis of the cages were oriented in a north-south direction. |
Sham exposure | A sham exposure was conducted. |
周波数 | 300 µHz |
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タイプ |
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ばく露時間 | intermittent, 6 min/hour for 8 hours/night on three consecutive nights |
ばく露の発生源/構造 |
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Whereas 10% of the animals that had been sham-exposed died within 24 h, 60% of the rats that had been exposed to the experimental magnetic fields simulating natural geomagnetic activity died during this period. These data indicate that correlational analyses between sudden unexplained death in epileptic patients and increased geomagnetic activity can be simulated experimentally in epileptic rats and that potential mechanisms might be testable directly.
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