研究のタイプ: 医学／生物学の研究 (experimental study)

[ラット顔面神経における外傷関連タンパク質のmRNAに対する携帯電話様電磁界の定量的影響] med./bio.

Qualitative Effect on mRNAs of Injury-Associated Proteins by Cell Phone Like Radiation in Rat Facial Nerves

著者: Yan JG, Agresti M, Zhang LL, Yan Y, Matloub HS
掲載誌: Electromagn Biol Med 2009; 28 (4): 383-390
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この実験研究は、ラットに毎日6時間（30分の休憩を挟んで3時間ばく露を2回）、18週間にわたり携帯電話電磁界のばく露を与え、顔面神経における外傷関連タンパク質（外傷時に上方調節される4つのタンパク質：Calcium ATP-ase、エンドセリン、神経細胞接着分子、神経増殖因子）のmRNAレベルを調べた。ばく露群6匹、対照群6匹とした。電磁界は3種類（SAR）：AMPSモード（1.9GHzディジタル、1.80 watts/kg）；CELLモード（800MHzディジタル、1.80 watts/kg）；PCSモード（800MHzアナログ、1.18watts/kg）。顔面神経から分離したmRNAをRT-PCR処理し、分析した結果、4つのmRNA全てが、程度は大きくないものの、上方調節されていたと報告している。

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研究目的(acc. to editor)

To check the hypothesis that cell phone irradiation can cause cellular damage to the rat facial nerve (buccal and mandibular branches) leading to increased mRNA transcription of injury-associated proteins.

詳細情報

Six rats were exposed and six rats were sham-exposed (Remark of EMF-Portal editor: The actual number of rats used for each exposure is not specified in this article).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 800 MHz
ばく露時間: 2 times 3 hr / day (with 30 min rest period between exposures), on 7 days/week for 18 weeks
AMPS mode
  • SAR: 1.8 W/kg (at 2.2 cm distance)
  • 電力: 6.3 mW minimum
  • 電力: 607 mW maximum
ばく露2: 800 MHz
ばく露時間: 2 times 3 hr / day (with 30 min rest period between exposures), on 7 days/week for 18 weeks
Cell mode
  • SAR: 0.9 W/kg (at 2.2 cm distance)
  • 電力: 0.01 mW minimum
  • 電力: 487 mW maximum
ばく露3: 1.9 GHz
ばく露時間: 2 times 3 hr / day (with 30 min rest period between exposures), on 7 days/week for 18 weeks
PCS mode
  • SAR: 1.18 W/kg (at 2.2 cm distance)
  • 電力: 0.01 mW minimum
  • 電力: 335 mW maximum

ばく露1

主たる特性
周波数 800 MHz
タイプ
  • electromagnetic field
ばく露時間 2 times 3 hr / day (with 30 min rest period between exposures), on 7 days/week for 18 weeks
Additional information AMPS mode
Additional information analog
ばく露装置
ばく露の発生源／構造
  • Nokia 3588i mobile phone
Distance between exposed object and exposure source 1 cm
ばく露装置の詳細 cell phone placed bewtween two tubes each holding a rat
Sham exposure A sham exposure was conducted.
Additional information The actual number of rats used for each exposure and their precise position in regard to the mobile phone is not specified in this article.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1.8 W/kg - - - at 2.2 cm distance
電力 6.3 mW minimum - - -
電力 607 mW maximum - - -

ばく露2

主たる特性
周波数 800 MHz
タイプ
  • electromagnetic field
ばく露時間 2 times 3 hr / day (with 30 min rest period between exposures), on 7 days/week for 18 weeks
Additional information Cell mode
Additional information digital
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Distance between exposed object and exposure source 1 cm
Sham exposure A sham exposure was conducted.
Additional information The actual number of rats used for each exposure and their precise position in regard to the mobile phone is not specified in this article.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 0.9 W/kg - - - at 2.2 cm distance
電力 0.01 mW minimum - - -
電力 487 mW maximum - - -

ばく露3

主たる特性
周波数 1.9 GHz
タイプ
  • electromagnetic field
ばく露時間 2 times 3 hr / day (with 30 min rest period between exposures), on 7 days/week for 18 weeks
Additional information PCS mode
Additional information digital
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Distance between exposed object and exposure source 1 cm
Sham exposure A sham exposure was conducted.
Additional information The actual number of rats used for each exposure and their precise position in regard to the mobile phone is not specified in this article.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1.18 W/kg - - - at 2.2 cm distance
電力 0.01 mW minimum - - -
電力 335 mW maximum - - -

Reference articles

  • Yan JG et al. (2008): [携帯電話ばく露後のラット脳での特異的mRNAレベルのアップレギュレーション]
  • Yan JG et al. (2007): [ラット精子の運動性に対する携帯電話からの電磁放射の影響]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • peripheral nerve system
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

All four mRNAs were up-regulated in the exposed group compared to the control group in both nerve sampIes. These differences were statistically significant for all four proteins in the mandibular branch and two for the buccal branch. The mandibular nerve showed a higher and broader level of upregulation than the buccal nerve.
The authors conclude that these upregulations have occurred in the cell phone exposed group because there have been injuries to the surrounding nerve tissue. The authors further conclude if the use of these cell phones continues, there most likely will be permanent damage to these tissues over the years and the likelihood of tumors, cancers, and system failures will potentially increase.

研究の種別:

研究助成

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