この研究は、両性のフィッシャー344ラットを用い、血液脳関門(BBB)に対する高周波電磁界(EMF)の生物学的影響を調べた。ばく露用TEM内で、915 MHzマイクロ波の連続波(CW)およびパルス変調波(パルス電力およびパルス間隔は変化させた)のばく露を行なった。連続波およびパルス波の電力は0.001 Wから10 Wまで、ばく露時間は2分から960分まで、それぞれ変化させた。実験では、電源ONのTEMセルに4 - 6 匹のばく露ラットを、電源OFFのTEMセルに2 - 4匹の対照ラットを入れ、ランダムに配置した。ラットは無麻酔でばく露を受けた。ばく露後、抱水クロラール麻酔下で脳を灌流固定した。脳を生理食塩水で3 - 4分間灌流し、その後4 %ホルムアルデヒドで5 - 6分間灌流固定した。脱水、パラフィン包埋して、全脳の冠状切片(5 μm厚)を作成し、アルブミンおよびフィブリノーゲンの病理学的漏出を免疫組織化学的に検査した。その結果、種々のばく露条件のマイクロ波ばく露を受けたラットは合計で630 匹、対照ラットは372匹であった;全ばく露ラットにおいて、病理学的変化が見られたラットの割合244/630で、対照ラット(62/372)とは有意差があった(p < 0.0001);ばく露ラットをSARレベルでグループ化すると、1.5 J/ kg以上のすべてのレベルで.有意差があった;パルス波ばく露では170/481、連続波ばく露では74/149で、いずれも対照群とは有意差があり、パルス波と連続波の間にも有意差があった、と報告している。
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To study the permeability of blood-brain barrier to endogenous albumin and fibrinogen during exposure to microwaves. Rats were exposed to 915 MHz microwaves as continuous wave and pulse-modulated at various repetition rates.
ばく露 | パラメータ |
---|---|
ばく露1:
915 MHz
Modulation type:
CW
ばく露時間:
continuous for 2 min to 960 min
|
|
ばく露2:
915 MHz
Modulation type:
pulsed
ばく露時間:
continuous for 2 min to 960 min
|
|
ばく露3:
915 MHz
Modulation type:
pulsed
ばく露時間:
continuous for 2 min to 960 min
|
|
ばく露4:
915 MHz
Modulation type:
pulsed
ばく露時間:
continuous for 2 min to 960 min
|
|
ばく露5:
915 MHz
Modulation type:
pulsed
ばく露時間:
continuous for 2 min to 960 min
|
|
ばく露6:
915 MHz
Modulation type:
pulsed
ばく露時間:
continuous for 2 min to 960 min
|
In each experiment, 4-6 rats with 4 controls were randomly placed in excited and non-excited TEM cells, respectively.
周波数 | 915 MHz |
---|---|
タイプ |
|
特性 |
|
ばく露時間 | continuous for 2 min to 960 min |
Modulation type | CW |
---|
ばく露の発生源/構造 | |
---|---|
チャンバの詳細 | The TEM cell was enclosed in a wooden box which supported the outer conductor and central plate. The outer conductor made of brass mesh was attached to the inner walls of the box. The central plate or septum was made of aluminium and was held up by Teflon braces which were screwed to the inner side walls. |
ばく露装置の詳細 | Rats were placed in plastic trays to avoid contact with the central plate and outer conductor. |
Sham exposure | A sham exposure was conducted. |
周波数 | 915 MHz |
---|---|
タイプ |
|
特性 |
|
ばく露時間 | continuous for 2 min to 960 min |
Modulation type | pulsed |
---|---|
Pulse width | 0.57 ms |
Repetition frequency | 217 Hz |
Pulse type | rectangular |
ばく露の発生源/構造 |
|
---|---|
Sham exposure | A sham exposure was conducted. |
周波数 | 915 MHz |
---|---|
タイプ |
|
特性 |
|
ばく露時間 | continuous for 2 min to 960 min |
Modulation type | pulsed |
---|---|
Pulse width | 6.6 ms |
Repetition frequency | 50 Hz |
Pulse type | rectangular |
ばく露の発生源/構造 |
|
---|---|
Sham exposure | A sham exposure was conducted. |
周波数 | 915 MHz |
---|---|
タイプ |
|
特性 |
|
ばく露時間 | continuous for 2 min to 960 min |
Modulation type | pulsed |
---|---|
Repetition frequency | 16 Hz |
Pulse type | rectangular |
ばく露の発生源/構造 |
|
---|---|
Sham exposure | A sham exposure was conducted. |
周波数 | 915 MHz |
---|---|
タイプ |
|
特性 |
|
ばく露時間 | continuous for 2 min to 960 min |
Modulation type | pulsed |
---|---|
Repetition frequency | 8.3 Hz |
Pulse type | rectangular |
ばく露の発生源/構造 |
|
---|---|
Sham exposure | A sham exposure was conducted. |
周波数 | 915 MHz |
---|---|
タイプ |
|
特性 |
|
ばく露時間 | continuous for 2 min to 960 min |
Modulation type | pulsed |
---|---|
Repetition frequency | 4 Hz |
Pulse type | rectangular |
ばく露の発生源/構造 |
|
---|---|
Sham exposure | A sham exposure was conducted. |
It was demonstrated that microwave exposure produces an unequivocal effect on the blood-brain barrier in the exposed rats. The frequency of pathological rats was 170/481among rats exposed to pulse modulated and 74/149 among rats exposed to continuous wave exposure. The results are both significantly different to their corresponding controls and the frequency of pathological rats after exposure to pulsed radiation is significantly less than after exposure to continuous radiation.
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