この研究は、単離したカエル坐骨神経調製物における複合活動電位（ＣＡＰ）の伝導に対するミリ波（連続波、40-52 GHz, 0.24-3.0 mW/cm2）の短期ばく露の影響を調べた。ＣＡＰは、神経の低頻度電気刺激（４対パルス/秒）または高頻度電気刺激（２０対パルス/秒）のどちらかで誘発された。低頻度電気刺激の場合、神経の機能状態に変化はなく、CAPの振幅、潜時、およびピーク潜時は数時間にわたって実質的に安定している。様々な一定周波数、または段階的な周波数変化（0.1 または0.01 GHz/分）を用いて、0.24-1.5 mW/cm2で、１０〜６０分間のマイクロ波照射を行なっても、ＣＡＰ伝導または神経不応性に検出可能な変化はなかった。2-3 mW/cm2の電界強度の照射では、テストＣＡＰ振幅の上昇と共に、ＣＡＰ潜時およびピーク潜時のわずかで一時的な減少が見られた。これらの変化は、ばく露の停止の直後に反転し、また定性的にも定量的にも従来の加熱法（0.3-0.4℃）による効果と同じであった。高頻度電気刺激の場合、条件付けCAPおよびテストCAPの振幅の漸進的かつ可逆的な減少が起き、潜時とピーク潜時が増加する。これらの変化は、ミリ波照射の有無にかかわらず同じであった。これらの知見を報告している。
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The aim of the study was to verify the existence of specific effects of millimeter waves on excitable tissues. The effects of a short-term exposure to millimeter waves on the compound action potential conduction in an isolated frog sciatic nerve preparation were investigated. Compound action potentials were evoked by either a low-rate or a high-rate electrical stimulation of the nerve (4 and 20 paired pulses/s, respectively).
| 周波数 | 41.15–51.7 GHz |
|---|---|
| タイプ |
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| ばく露時間 | 30 min |
| Modulation type | CW |
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| ばく露の発生源／構造 | |
|---|---|
| Distance between exposed object and exposure source | 0.052 m |
| ばく露装置の詳細 | sciatic nerves were laid in the slot of the exposure chamber and exposed under thin layer of mineral oil; the nerve was aligned with the E-field. |
| Sham exposure | A sham exposure was conducted. |
| 周波数 | 40.5–51.8 GHz |
|---|---|
| タイプ |
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| ばく露時間 | 10 - 60 min |
| Additional information | frequency changed in steps of 0.01 GHz/min or 0.1 GHz/min |
| Modulation type | CW |
|---|
| ばく露の発生源／構造 |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
The low-rate stimulation (field 1-9) did not change the functional state of the nerve, and the amplitude, latency, and peak latency of compound action potentials could stay virtually stable for hours. Microwave exposure for 10-60 min at 0.24-1.5 mW/cm², either at various constant frequencies or with a stepwise frequency change, did not cause any detectable alterations in compound action potential conduction.
The high-rate electrical stimulation produced gradual and reversible decrease of the amplitude of test compound action potentials and increased their latencies and peak latencies. These changes were essentially the same with and without irradiation, except for attenuation of the decrease of the test compound action potential amplitude. This effect was revealed at both field intensities, but was statistically significant only for certain frequencies of the irradiation. Within the studied limits, this effect appeared to be dependent on the frequency rather than on the intensity of the irradiation, but this observation requires additional experimental confirmation.
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