この研究は、ゼブラフィッシュ（学名Danio rerio）の神経行動および酸化ストレスに対する携帯電話（GSM900MP）の電磁放射ばく露（SARは1.34W/kg：1日1時間、14日間ばく露）の影響を調べた。その結果、社会的相互作用試験において、ばく露群は社会的刺激ゾーンで費やす時間が減少し、総泳動距離が増加した；新規水槽への投げ込み試験において、ばく露群は不安行動を示した；酸化ストレスパラメータもばく露群で有意に変化した；メラトニン投与によりばく露による神経行動、酸化ストレスへの影響は有意に回復した、と報告している。
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The effects of exposure of zebrafish to a 900 MHz electromagnetic field (GSM) on the behavior and oxidative stress in the brain and the influence of melatonin should be investigated.
Zebrafish were divided into 3 groups (n=40 each): 1) exposure to the electromagnetic field, 2) co-exposure to the electromagnetic field and melatonin (100 nM) and 3) control group.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
900 MHz
ばく露時間:
for 1 hour/day for 14 days
|
|
the melatonin co-exposure group (group 2) was exposed to 100 nM melatonin in 1 l of water daily for 1 hour prior to exposure to the mobile phone
| 周波数 | 900 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | for 1 hour/day for 14 days |
| ばく露の発生源／構造 |
|
|---|---|
| Distance between exposed object and exposure source | 1.2 cm |
| チャンバの詳細 | glass petri dish 3/4th filled with home tank water |
| ばく露装置の詳細 | two rooms were used; one room was equipped with a music system and a mobile phone for calling, the other was equipped with the called mobile phone and the fish; a piece of paper was placed above the petri dish with n=5 zebrafish and mobile handset was kept above the paper; during exposure, music was played continuously over the line; other electronic devices that could potentially emit radio frequency fields were not kept in the exposure room during the exposure period |
| Sham exposure | A sham exposure was conducted. |
| Additional information | the control group was exposed to the same protocol and conditions i.e. kept in beaker containing water devoid of melatonin and placed in petri dish but not exposed to mobile phone fields (remark EMF-Portal: hence, they were probably also not exposed to the music). |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| SAR | 1.34 W/kg | - | - | - | - |
All paramaters investigated in the study were significantly different in the exposure group (group 1) compared to the control group (group 3):
In the social interaction test, the time spent near the social stimulus zone was decreased and the total distance travelled was increased, indicating a change in social behavior. In the tank dive test, exposed fish showed anxiety as revealed by increases in the time spent in the tank's bottom half and in the number and duration of freezing bouts as well as by decreases in the distance travelled, velocity and number of entries to upper half of the tank. Exposed fish spent less time in the novel arm of the Y-Maze, indicating impaired learning.
In the brain, the enzyme activities of superoxide dismutase and catalase were decreased while the levels of reduced glutathione and lipid peroxidation were increased, showing compromised antioxidant defense.
A treatment with melatonin (group 2) significantly reversed all above mentioned effects induced by exposure (except for the distance travelled in the social interaction test).
The authors conclude that exposure of zebrafish to a 900 MHz electromagnetic field (GSM) might change the behavior and increase the oxidative stress in the brain and that melatonin might attenuate these effects.
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