研究のタイプ: 医学／生物学の研究 (experimental study)

[携帯電話ばく露に伴う電磁界による妊娠早期胎盤絨毛組織でのタンパク質発現変化に関するプロテオミック分析] med./bio.

Proteomic analysis on the alteration of protein expression in the early-stage placental villous tissue of electromagnetic fields associated with cell phone exposure

著者: Luo Q, Jiang Y, Jin M, Xu J, Huang HF
掲載誌: Reprod Sci 2013; 20 (9): 1055-1061
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この研究は、正常な妊娠後、心理的理由により妊娠約50日での中絶手術を予定する女性40人を2群（ばく露群、擬似ばく露群；各20人）に分け、手術の20分前に、下腹部に市販の携帯電話からの電磁界のばく露（または擬似ばく露）を1時間与え、その後に摘出した胎盤絨毛組織でのタンパク質発現変化を調べた。携帯電話を腹部の臍から10cm離して置き、SARは1.6から8.8 W/kgであったと記している。タンパク質プロファイルの変化を2次元電気泳動解析により調べた。その結果、ばく露群では泳動パターン上の最大15箇所で、擬似ばく露群に比べ2倍から2.5倍の上昇または低下の有意な変化があった；変化した12種のタンパク質が同定された、と報告している。

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研究目的（著者による）

To investigate the possible changes induced by the exposure to a radiofrequency electromagnetic field in protein expression profile in human chorionic villous tissue (part of the placenta) of early pregnancy.

詳細情報

The women, gestational age about 50-60 days, were randomly divided into an exposure and a control group. After 20 minutes of exposure, an abortion was performed and the chorionic villous tissue was taken through the cervix. Tissue, collected from 6 exposed women and from 6 control women, was taken for proteome analysis.
The women underwent terminations of the pregnancies for psychological reasons.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: continuous for 20 min. (according to "materials and methods" section) or 1 h (according to abstract)?
  • 電力密度: 1 mW/cm² minimum
  • 電力密度: 40 mW/cm² maximum
  • SAR: 1.46 W/kg (according to "materials and methods" section)
  • SAR: 1.6 W/kg minimum (according to "abstract")
  • SAR: 8.8 W/kg maximum (according to "abstract")

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 20 min. (according to "materials and methods" section) or 1 h (according to abstract)?
ばく露装置
ばく露の発生源／構造
  • セルラ－電話
  • Sony Ericsson w300
ばく露装置の詳細 lower abdomens of the pregnant women were exposed by a commercially available cell phone (navel region); cell phone was in talk mode; distance of cell phone to abdomen 2.5 cm (according to "materials and methods" section) or 10 cm (according to abstract)?
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 1 mW/cm² minimum - - -
電力密度 40 mW/cm² maximum - - -
SAR 1.46 W/kg - - - according to "materials and methods" section
SAR 1.6 W/kg minimum - - according to "abstract"
SAR 8.8 W/kg maximum - - according to "abstract"
Additional parameter details

power flux density of the control group was 0.01-0.1 mW/cm²

Reference articles

  • Agarwal A et al. (2009): [ヒト精液に対する携帯電話ＲＦ電磁界の影響：インビトロのパイロット研究]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

Approximately, 2000 spots were detected in the two-dimensional gel electrophoresis. Among them, 9 proteins of the exposed group were significantly down-regulated and 6 proteins were significantly up-regulated compared to the control group. Out of these 15 spots, 12 proteins were identified. The protein expression of 3 proteins was verified using Western blot.
The authors conclude that electromagnetic fields from cell phones could alter the protein expression profile of chorionic villous tissue of the early pregnancy.

研究の種別:

研究助成

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