研究のタイプ: 医学／生物学の研究 (experimental study)

[中年ラットにおけるコルチコステロン、感情記憶及び神経炎症に対する900 MHz無線周波の影響] med./bio.

Effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats

著者: Bouji M, Lecomte A, Hode Y, de Seze R, Villegier AS
掲載誌: Exp Gerontol 2012; 47 (6): 444-451
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この実験研究は、若年（6週齢）および中年（12月齢）のラットのグリア原線維酸性たんぱく質（GFAP）発現に対する携帯電話のGSM信号（900 MHz；SAR = 6W/kg；15分間ばく露1回）ばく露の影響を調べた。調べた影響評価項目は、脳のインターロイキン（IL）-1β、IL-6、コルチコステロンの血中レベル、感情記憶である。その結果、前回公表した結果に反し、GSM信号の急性ばく露は星状グリア細胞の活性化を引き起こさなかったが、中年ラット群において嗅球のIL-1β上昇と文脈的感情記憶の増強が、また若年ラット群におい血中コルチコステロンレベルの上昇が引き起こされた等々を報告している。

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研究目的（著者による）

To assess glial fibrillary acidic protein (GFAP) levels in the brain of six week-old and twelve month-old rats, after exposure to GSM 900 MHz. Also interleukin expression and plasma levels of corticosterone and the emotional memory were examined.

詳細情報

For both ages rats were randomly assigned to either an exposure group or a sham exposure group (n=8-9 per group). On the first day of the experiment the rats were subjected to a fear conditioning training. After 48 hours they were exposed to an GSM signal for 15 minutes and tested for the sound memory. After additional 48 hours, contextual memory was tested and immediately followed by sacrifice.
Additionally, twelve control groups (n=6 per group) with six week-old rats were assigned which were sacrificed 30 minutes, 5 hours or 24 hours following (a) daily handling (cage control), (b) a single, 15 minutes, 6 W/kg exposure, (c) a single, 15 minutes sham exposure or (d) a 15 minutes sham exposure followed by a fear conditioning session.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 15 min

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 15 min
Modulation
Modulation type pulsed
Duty cycle 12.5 %
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源／構造
  • loop antenna
ばく露装置の詳細 animal placed in a Plexiglas rocket capped with a truncated cone; rocket body lined with air holes; loop antenna fixed to the rocket's cap
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 6 W/kg - - - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

Acute GSM 900 MHz exposure did not alter the level of glial fibrillary acidic protein in the brain of rats.
An increase in IL-1ß in the olfactory bulb in exposed 12 month-old rats was found in comparison to 6 week-old rats and sham exposed ones. Additionally, an increased corticosterone level in 6 week-old exposed rats and an enhanced emotional memory in 12 month-old exposed rats was found in comparison to sham exposed rats.
The authors concluded that the data showed an age-dependent response to GSM exposure in neuro-immunity, stress and behavioural parameters.

研究の種別:

研究助成

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