研究のタイプ: 医学／生物学の研究 (experimental study)

[ラットの蝸牛細胞に対する900 MHz電磁界ばく露の影響：歪成分耳音響放射の評価] med./bio.

Effects of 900 MHz electromagnetic fields exposure on cochlear cells' functionality in rats: Evaluation of distortion product otoacoustic emissions

著者: Galloni P, Lovisolo GA, Mancini S, Parazzini M, Pinto R, Piscitelli M, Ravazzani P, Marino C
掲載誌: Bioelectromagnetics 2005; 26 (7): 536-547
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この研究は、ラットの蝸牛の機能に対する携帯電話様のマイクロ波電磁放射の影響可能性を評価した。蝸牛の外有毛細胞（OHC）の状態を表す指標として、歪成分耳音響放射（DPOAE）の振幅を選んだ。実験プロトコルには、さまざまな周波数（ラットの蝸牛感受性スペクトルの低周波域）、強度、ばく露期間を用いた。DPOAE検査は、マイクロ波ばく露の前、最中、後に実施された。その結果、マイクロ波ばく露によってラット蝸牛の機能の有意な変動の証拠は得られなかった、と報告している。

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研究目的（著者による）

To evaluate the possible effects of cellular phone-like emissions on the functionality of rat's cochlea.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 936 MHz
Modulation type: CW
ばく露時間: repeated daily exposure for 3 h per day for 5 days
  • SAR: 1 W/kg average over mass (whole body)
ばく露2: 923 MHz
Modulation type: CW
ばく露時間: repeated daily exposure for 3 h per day for 5 days
  • SAR: 1 W/kg average over mass (partial body)
ばく露3: 960 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure for 3 h per day for 5 days
  • SAR: 1 W/kg average over mass
ばく露4: 900 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure for 2 h per day for 5 days per week for 4 weeks
  • SAR: 2 W/kg average over mass

General information

During the treatment the rats were inserted in Perspex jigs, which were cylindrical tubes with a cone-shaped head end and a lockable piston in the tail end to prevent rats from backing out of the restrainer. This assembly was able to keep them as motionless as possible and at the same time cause minimal restrain stress.

ばく露1

主たる特性
周波数 936 MHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 repeated daily exposure for 3 h per day for 5 days
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1 W/kg average over mass 測定値および計算値 whole body -

ばく露2

主たる特性
周波数 923 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 repeated daily exposure for 3 h per day for 5 days
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 antennas have been built using the coplanar line technique on a dielectric substrate; line terminated with a rectangular loop printed on the substrate; electromagnetic matching with the power supply is done using an electric contact sliding on the substrate
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1 W/kg average over mass 測定値および計算値 partial body -
測定および計算の詳細

Numerical simulations of the local SAR in tissues have been performed using a commercial code (XFDTD code) on a realistic model of rat head; with the fundamental tissues (skin, fat, muscle, brain, bone), while measurements have been carried out with miniaturized probes on homogenous phantoms (brain equivalent tissue) and in the inner ear of a rat's cadaver. The measures in the sacrificed rat have been performed by power pulse method using an electronic thermometer and a fiberoptic probe. Data from numerical and experimental dosimetry showed a good agreement.

ばく露3

主たる特性
周波数 960 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 repeated daily exposure for 3 h per day for 5 days
Modulation
Modulation type pulsed
ばく露装置
ばく露の発生源／構造
  • same as E2
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1 W/kg average over mass 測定値および計算値 - -

ばく露4

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 repeated daily exposure for 2 h per day for 5 days per week for 4 weeks
Modulation
Modulation type pulsed
ばく露装置
ばく露の発生源／構造
  • same as E2
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 2 W/kg average over mass 測定値および計算値 - -

Reference articles

  • Marino C et al. (2000): [蝸牛受容体へのマイクロ波（900MHz）の影響：ばく露装置と予備的結果]
  • Chou CK et al. (1999): [ハンドヘルド無線電話からのRF電磁界への人体ばく露を模擬したラット頭部ばく露システムの開発]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 感覚器
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

No significant difference due to exposure to microwaves has been evidenced (no changes in the otoacoustic emission parameters).

研究の種別:

研究助成

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