研究のタイプ: 医学／生物学の研究 (experimental study)

[ミオグロビンの構造力学とリガンド結合特性にマイクロ波放射ばく露は影響するか？] med./bio.

Are the conformational dynamics and the ligand binding properties of myoglobin affected by exposure to microwave radiation?

著者: Bismuto E, Mancinelli F, d'Ambrosio G, Massa R
掲載誌: Eur Biophys J 2003; 32 (7): 628-634
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この研究は、マグロのミオグロビンの構造および機能の特性に対するマイクロ波（1.95GHz）の影響を調べた。ミオグロビンを入れた液体に、SAR値51mW/gの2.5時間ばく露を与えた。その結果、この周波数領域での吸収スペクトスコピ、円偏光二色性、蛍光放出の減衰に何も影響は見られなかった、と報告している。

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研究目的（著者による）

To study the effects of microwaves on structural and functional properties of tuna myoglobin at 1.95 GHz, a frequency used by new wireless microwave communication systems.

詳細情報

In order to state safety guidelines it seems appropriate to start by excluding non-specific effects on dynamic and structural properties of fundamental biomolecules such as proteins (proteins are susceptible, in principle, to the action of electromagnetic fields).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1.95 GHz
Modulation type: CW
ばく露時間: continuous for 2.5 h

ばく露1

主たる特性
周波数 1.95 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 2.5 h
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
  • 導波管
  • 110 x 55 x 500 mm, surrounded by a thermostated water jacket
ばく露装置の詳細 The sample (3 ml of solution) in a polystyrene cuvette (10 x 10 x 35 mm) was placed vertically in the waveguide where the incident E field (vertical) was maximum.
Additional information The sample temperature at the beginning was 25 ± 0.1 °C, it increased to 30 ± 0.1 °C in about 30 min, and it remained at that value for the rest of the exposure period.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 51 mW/g mean 電力損失による決定値 - ± 1 mW/g
電界強度 197 V/m effective value 計算値 - -
測定および計算の詳細

Power meters and sensors were used to measure the incident, reflected, and transmitted powers for determining the average SAR during the actual exposure. The SAR value was related to the electric field effective value by E = (ρ/σ)SAR1/2 [Chou et al., 1996].

Reference articles

  • Chou CK et al. (1996): [無線周波電磁界ばく露：実験的ドシメトリに関する教育的レビュー]

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム（著者による）

The data indicate that, at least for the native state of the protein, microwave perturbation does not affect the structural organization of the myoglobin or its internal dynamics and CO binding affinity.

研究の種別:

研究助成

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