研究のタイプ: 医学／生物学の研究 (experimental study)

[パルス化マイクロ波への急性ばく露はペンチレンテトラゾールによる痙攣にもそのような麻痺のクロルジアゼポキシドによる保護にも影響しない] med./bio.

Acute exposure to pulsed microwaves affects neither pentylenetetrazol seizures in the rat nor chlordiazepoxide protection against such seizures

著者: Pappas BA, Anisman H, Ings R, Hill DA
掲載誌: Radiat Res 1983; 96 (3): 486-496
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この研究は、薬理学的効果とマイクロ波ばく露の関連を、３つの実験により調べた。その結果、パルス化2.70 GHzマイクロ波は、20 mW/ cm2までの電力密度では、ペンチレンテトラゾールの発作誘発効果、またはその発作を抑制するクロルジアゼポキシドの効果に影響を与える証拠は得られなかった；マイクロ波ばく露は、クロルジアゼポキシドの発作抑制効果を変えることなく、同薬剤の低体温誘発効果を打ち消した；これは、マイクロ波による熱効果と薬理学的効果の間の解離を強調している、と報告している。

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研究目的（著者による）

To determine whether brief pulsed microwave exposures altered susceptibility to pentylenetetrazol (PTZ, induces seizures by blocking the inhibitory effect of GABA as well as by a direct effect on neuronal membranes) seizures or the efficacy of chlordiazepoxide (CDZ) for counteracting PTZ seizures.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.7 GHz
Modulation type: pulsed
ばく露時間: continuous for 30 min

ばく露1

主たる特性
周波数 2.7 GHz
タイプ
  • electromagnetic field
特性
  • far field
偏波
  • circular
ばく露時間 continuous for 30 min
Modulation
Modulation type pulsed
Pulse width 2 µs
Repetition frequency 500 Hz
Pulse type rectangular
ばく露装置
ばく露の発生源／構造
Distance between exposed object and exposure source 110 cm
チャンバの詳細 The antenna was a multiridged rectangular horn with a diagonal aperture of 20.5 cm radiating vertically downward into an anechoic chamber of 1.7 m x 2.6 m x 2.6 m.
ばく露装置の詳細 Rats were placed in vented circular acrylic cages of 15.3 cm diameter and 9.5 cm height with 6 mm thick acrylic lids and floors.
Sham exposure A sham exposure was conducted.
Additional information Up to four rats could be exposed at a time at four positions of equal power density spaced about 3 λ apart. However, due to handling constraints, only two rats were exposed at a time.
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 5 mW/cm² - 測定値 - -
SAR 0.75 W/kg - 測定値 - -
電力密度 10 mW/cm² - 測定値 - -
SAR 1.5 W/kg - 測定値 - ± 0.1 W/kg
電力密度 15 mW/cm² - 測定値 - -
SAR 2.25 W/kg - 測定値 - -
電力密度 20 mW/cm² - 測定値 - -
SAR 3 W/kg - 測定値 - -
測定および計算の詳細

The power to the antenna was controlled and measured using a hybrid coaxial waveguide network including a waveguide quadrature variable coupler and high power water load. Power densities were measured inside the cages using a broadband isotropic radiation monitor. The SARs were determined by measuring rectal temperature changes in anaesthetised rats irradiated for 3 min at 144 mW/cm² [Gandhi et al., 1979]. The measured SAR was in good agreement with the value of 2 W/kg at 10 mW/cm² calculated according to the Radiofrequency Radiation Dosimetry Handbook [Durney et al., 1980].

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

The experiments failed to provide consistent evidence for an effect of 2.70 GHz pulsed microwave exposure up to 20 mW/cm² on PTZ-induced seizures or on the efficacy of CDZ for counteracting such seizures. One consistent result across all experiments was that pulsed microwaves elevated core temperatures and this was proportional to the power density. Microwave exposure counteracted the hypothermic effects of CDZ without altering its anti-seizure efficacy. This underscores the dissociation between thermal and pharmacological effects of microwave exposure.

研究の種別:

研究助成

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