この研究は、、シナプシンIを対象に、マイクロ波放射が神経毒性的であるか否かを調べた。シナプシンIは、全てのニューロンに存在するニューロン特異的リンタンパク質であり、シナプス終末に局在し、シナプス小胞を伴う。 O'CallaghanおよびMillerは、このニューロン特異的タンパク質を調べることで、神経毒性の信頼できる指標が得られることを実証した。ここでは、まず、マイクロ波照射がシナプシンIのレベルに何らかの影響を与えるか否かを明らかにするため、シナプシンIに放射免疫測定を適用した。その結果、マイクロ波の急性および慢性ばく露はどちらも、シナプシンIレベルに検出可能な影響を与えなかった、と報告している。次に、マイクロ波照射を受けたラットから単離されたシナプトソーム中のシナプシンIのカルシウム依存性リン酸化を試験した。シナプトソーム中のシナプシンIのリン酸化は、ニューロン伝達のシナプス前での多数の構成成分を反映する。試験の結果、軽度のハイパサーミアを生じるレベル以下の強度では、シナプシンIのリン酸化へのマイクロ波照射の影響は観察されなかった、と報告している。
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To determine whether microwave exposure might be neurotoxic, the effects of microwave exposure on the protein synapsin I have been studied.
Synapsin I is a neuron-specific phosphoprotein that is present in all neurons, where it is located to the presynaptic terminal and it is associated with synaptic vesicles. Calcium-dependent phosphorylation of synapsin I in synaptosomes isolated from rats exposed to microwaves was also examined. The phosphorylation of synapsin I reflects numerous components of the presynaptic aspect of neuronal transmission.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
2 GHz
Modulation type:
CW
ばく露時間:
continuous for 30 min
|
|
|
ばく露2:
2 GHz
Modulation type:
pulsed
ばく露時間:
continuous for 30 min
|
|
|
ばく露3:
2.08 GHz
Modulation type:
pulsed
ばく露時間:
continuous for 30 min
|
|
|
ばく露4:
2.8 GHz
Modulation type:
pulsed
ばく露時間:
continuous for 30 min
|
|
|
ばく露5:
2.8 GHz
Modulation type:
pulsed
ばく露時間:
continuous for 30 min
|
|
|
ばく露6:
500 MHz
Modulation type:
AM
ばく露時間:
continuous for 30 min
|
|
|
ばく露7:
450 MHz
Modulation type:
AM
ばく露時間:
continuous for 30 min
|
|
|
ばく露8:
2.4 GHz
Modulation type:
CW
ばく露時間:
almost continuous, 23 h/day, for 1 week
|
| 周波数 | 2 GHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | continuous for 30 min |
| Modulation type | CW |
|---|
| 周波数 | 2 GHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | continuous for 30 min |
| Modulation type | pulsed |
|---|---|
| Pulse width | 10 ms |
| Repetition frequency | 6,000 Hz |
| ばく露の発生源／構造 |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| 周波数 | 2.08 GHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | continuous for 30 min |
| Modulation type | pulsed |
|---|---|
| Pulse width | 10 ms |
| Repetition frequency | 6,000 Hz |
| ばく露の発生源／構造 |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| 周波数 | 2.8 GHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | continuous for 30 min |
| Modulation type | pulsed |
|---|---|
| Pulse width | 10 ms |
| Repetition frequency | 6,000 Hz |
| ばく露の発生源／構造 |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| 周波数 | 2.8 GHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | continuous for 30 min |
| Modulation type | pulsed |
|---|---|
| Pulse width | 10 ms |
| Repetition frequency | 500 Hz |
| ばく露の発生源／構造 |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| 周波数 | 2.4 GHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | almost continuous, 23 h/day, for 1 week |
| Additional information | Guy, A. W.; Chou, C. K. System for quantitative chronic exposure of populations of rodents to UHF fields. In: Johnson, C. C.; Shore, M. L., eds. Biological effects of electromagnetic waves: Selected papers. HEW Publication (FDA) 77-8011; 1975:38-42. |
| Modulation type | CW |
|---|
| ばく露の発生源／構造 | |
|---|---|
| チャンバの詳細 | The circular waveguide system was described by Guy and Chou [1975]. The TE11 mode was excited by two radial probes located 90° apart and driven with a phase difference of 90°. |
| ばく露装置の詳細 | Animals were unrestrained in cages. |
| Sham exposure | A sham exposure was conducted. |
Neither acute nor chronic exposure to microwaves had any detectable effect on synapsin I levels. At intensities below that required to produce mild hyperthermia, no effects of microwave exposure were seen on synapsin I phosphorylation. Short-term exposure to microwaves at power densities that produced modest hyperthermia significantly decreased the calcium-dependent phosphorylation of synapsin I, but this effect was not seen after chronic, hyperthermic exposure.
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