この研究は、超低周波電磁界（ELF-EMF）へ8−10日間ばく露した哺乳類中枢神経系の巨大シナプス終末（calyx of Held）でのカルシウム電流および膜容量を測定した。その結果、ばく露は、神経終末でのカルシウムチャネル発現を増加させ、カルシウム依存的に小胞エンドサイトーシスおよびシナプス可塑性を促進することが示された、と報告している。
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The effects of exposure of young mice to a 50 Hz magnetic field on synaptic transmission and synaptic plasticity in the brain should be investigated.
Investigations were conducted at the Calyx of Held, a particularly large synapse in the mammalian brain.
Exposure started on the day of birth.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
50 Hz
ばく露時間:
continuous for 8 to 10 days
|
|
Compared to the control group, exposure to the magnetic field significantly increased the calcium influx upon electrical stimulation and all forms of vesicle endocytosis. However, exposure did not affect the size of the readily releasable pool or exocytosis.
Exposure to the magnetic field also significantly increased the amplitude of post-tetanic potentiation compared to the control group without influencing its time course.
Investigating the underlying mechanisms of action, a significantly increased protein expression and gene expression of P/Q and N subtype calcium ion channels was found in exposed samples compared to the control group. The increased calcium influx upon stimulation in exposed samples might have been realized via these channels.
The authors conclude, that exposure of young mice to a 50 Hz magnetic field might increase vesicle endocytosis and synaptic plasticity in a calcium-dependent manner by increasing calcium ion channel expression at nerve terminals in the brain.
(remark EMF-Portal: group sizes unclear)
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