研究のタイプ: 医学／生物学の研究 (experimental study)

[ペントキシフィリンおよび電磁界はラットの骨折治癒を改善した] med./bio.

Pentoxifylline and electromagnetic field improved bone fracture healing in rats

著者: Atalay Y, Gunes N, Guner MD, Akpolat V, Celik MS, Guner R
掲載誌: Drug Des Devel Ther 2015; 9: 5195-5201
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この研究は、ウィスター雄ラット（n=80）の大腿骨の骨折治癒に対するホスホジエステラーゼ阻害剤ペントキシフィリン（PTX：50 mg/kg/日、腹腔内投与）、電磁界（EMFs：1.5±0.2mT、50 Hz、6時間／日）および両者の組合せの処置の効果を調べた。ラットは4群（各n=20）、無処置群、PTX群、EMFs群、組合せ処置群に分けた。その結果、無処置群に比べ、PTX群、EMFs群での治癒が有意に改善した；しかし組合せ処置群では無処置群に比べで治癒の改善はなかった､と報告している。

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研究目的（著者による）

The effects of exposure of rats to a 50 Hz magnetic field or pentoxifylline and the effects of co-exposure on bone fracture healing should be investigated.

詳細情報

Pentoxifylline is a phosphodiesterase inhibitor, which has a positive effect on bone formation. Consequentially, a positive effect on bone fracture healing was hypothesized.
80 male rats with an experimental femur fracture were randomly divided into the following groups (n=20 each): 1) exposure to the magnetic field, 2) intraperitoneal injection of pentoxifylline (50 mg/kg/day), 3) co-exposure to the magnetic field and pentoxifylline, 4) control group (no exposure). After 21 days and 30 days, 10 rats of each group were killed and investigated, respectively. Four slides from each fracture were examined.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 6 hours/day for 21 days
ばく露2: 50 Hz
ばく露時間: continuous for 6 hours/day for 30 days

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 6 hours/day for 21 days
ばく露装置
ばく露の発生源／構造
チャンバの詳細 flexiglass cages
ばく露装置の詳細 exposure setup was placed inside a Faraday cage; two identical pairs of Helmholtz coils with a wrap-around number of 125, internal diameter of 47 cm and at distance intervals of 70 cm, were placed vertically in the Faraday cage; coils were powered with 48 V and 40 A
パラメータ
測定量 値 種別 Method Mass 備考
磁束密度 1.5 mT mean 測定値 - ± 0.2 mT
Additional parameter details

the background magnetic field was found to be 1.5 ± 0.2 mT, 50 Hz frequency and peak duration 1.3 ms (remark EMF-Portal: same value as exposure, possibly a typing error)

ばく露2

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 6 hours/day for 30 days
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
パラメータ
測定量 値 種別 Method Mass 備考
磁束密度 1.5 mT mean 測定値 - ± 0.2 mT

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

Bone healing was significantly increased after 21 days and 30 days in rats exposed to the magnetic field (group 1) or treated with pentoxifylline (group 2) compared to the control group (group 4). However, co-exposure (group 3) did not show any significant difference compared to the control group.
The authors conclude that exposure of rats to a 50 Hz magnetic field or pentoxifylline alone might have positive effects on bone fracture healing. However, co-exposure does not seem to have any positive effect.

研究の種別:

研究助成

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