この研究は、ウイスターアルビノ系の妊娠母ラットとその出生仔に超低周波電界（ELF-EFs：50 Hz、12 kV/m、1時間／日）のばく露を与え、発達への影響を出生仔が成獣になった時の視覚誘発電位（VEPs）および体性感覚誘発電位（SEPs）を指標に調べた。また、これらの誘発電位の変化と脂質過酸化の関係を、チオバルビツール酸反応性物質（TBARS）レベルを指標に調べた。出生仔について、対照群（C）、出生前のみのばく露群（Pr）、出生前+出生後ばく露群（PP）、出生後のみのばく露群（Po）で実験した。出生後ばく露は68日間。出生後90日目に、全ての群のラットでVEPおよびSEPを測定した。その結果、C群に比べ、全てのばく露群でのVEPの各成分の潜時が有意に遅延した；SEPにおいても，それぞれのばく露群でいくつかの成分の潜時が遅延した；脳および網膜のTBARSレベルの有意な増加が観察された、と報告している。
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The effects of prenatal and/or postnatal exposure of rats to a 50 Hz electric field on evoked potentials and lipid peroxidation in the brain and retina should be investigated.
Pregnant rats were divided into four groups: 1) prenatal exposure to the electric field and postnatal sham exposure, 2) prenatal sham exposure and postnatal exposure, 3) prenatal and postnatal exposure and 4) only sham exposure (control group). After 22 days, young animals were separated from their mothers and after further 68 days, they were killed and investigated. Each group included 10 female rats which were taken from 10 mothers.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
50 Hz
ばく露時間:
daily for 1 hour/day every during pregnancy
prenatal exposure
|
|
|
ばく露2:
50 Hz
ばく露時間:
daily for 1 hour/day for 90 days after birth
postnatal exposure
|
|
|
ばく露3:
50 Hz
ばく露時間:
daily for 1 hour/day during pregnancy and for 90 days after birth
prenatal and postnatal exposure
|
| 周波数 | 50 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | daily for 1 hour/day every during pregnancy |
| Additional information | prenatal exposure |
| ばく露の発生源／構造 |
|
|---|---|
| チャンバの詳細 | plastic cage (42.5 cm x 26.5 cm x 18.5 cm) |
| ばく露装置の詳細 | plate capacitor consisted of parallel copper plates (50 x 80 cm) plated with zinc (2 mm thickness); in order to produce uniform field, the comers of parallel plates were rounded; plates were placed upright on wooden stands and positioned parallel to each other at 50 cm distance; cables were connected to the center of the plates on their outer surfaces to preserve field homogeneity; the plastic cage was placed in the center between the two plates at equal distance; four animals in one cage were exposed at one time and could move freely |
| Sham exposure | A sham exposure was conducted. |
The latencies of all visual evoked potential components in all exposure groups (groups 1-3) were significantly prolonged compared to the control group. No differences in amplitudes were found between the groups.
For somatosensory evoked potentials, all potential components of group 3 (prenatal and postnatal exposure), 3 components of group 2 (postnatal exposure) and 2 components of group 1 (prenatal exposure) were significantly delayed compared to the control group. Moreover, group 3 showed significantly increased amplitude peak-to-peak values of potential components compared to the control group.
Lipid peroxidation in the brain was significantly increased in groups 1 and 2 compared to the control group. In the retina, lipid peroxidation was significantly increased in all exposure groups compared to the control group.
No differences in general health and body weight were found between animals of all groups.
The authors conclude that prenatal and/or postnatal exposure of rats to a 50 Hz electric field might influence evoked potentials. Lipid peroxidation in the brain and retina might be associated with this effect.
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