研究のタイプ: 治療に関する研究 (experimental study)

[体腔内ハイパサーミア：個人別の膣用プロトタイプアプリケータの製作と加熱パターン] med. app.

Intracavitary hyperthermia: construction and heat patterns of individualized vaginal prototype applicators

著者: Valdagni R, Amichetti M, Cristoforetti L
掲載誌: Int J Hyperthermia 1988; 4 (5): 457-466
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この研究は、手術不能または以前に放射線療法を受けたことのある子宮頸部再発がんの患者向けの低線量放射線療法および温熱療法を考慮にいれて、腟加温用のプロトタイプアプリケータの開発、および筋肉等価ファントムでの試験結果を報告している。

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研究目的（著者による）

Patients with inoperable or previously irradiated cervical carcinoma recurrences pose a challenging problem to the clinician. Low-dose irradiation and hyperthermia seem to be a promising method for treatments in previously treated patients. In order to heat the vaginal apex, individualized prototype applicators utilizing microwave antennas were constructed and tested in muscle equivalent phantom. Preliminary data from clinical utilization are also included.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 950 MHz
ばく露時間: 60 s
  • 電力: 17 W (0.9 W reflected power)
ばく露2: 950 MHz
ばく露時間: 120 s
  • 電力: 14 W (reflected power 0.1 W)
ばく露3: 915–950 MHz
ばく露時間: once a week for a total of 4 sessions, each session lasting 30 min
  • 電力: 14 W (reflected power 0.1 W)

ばく露1

主たる特性
周波数 950 MHz
タイプ
  • electromagnetic field
ばく露時間 60 s
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 Muscle equivalent phantom (75% water, 2% NaCl, 10 % Tx-150 as gelling agent, 13% polyethylene powder, dielectric constant of 52.89 and electrical conductivity of 2.68 S/m) placed inside a plexiglas plastic container (20 cm x 20 cm x 10 cm)
Additional information Heating patterns were obtained with the following set-ups with the microwave power same for all of these set-ups: 1) a single and straight antenna in direct contact with phantom material 2) a single and straight antenna positioned within a cylindrical cellulose acetate support and in direct contact with the phantom material 3) a single antenna curved on the emitting region and positioned within a cylindrical cellulose acetate support with the support not filled with phantom material.
パラメータ
測定量 値 種別 Method Mass 備考
電力 17 W - 指定なし - 0.9 W reflected power

ばく露2

主たる特性
周波数 950 MHz
タイプ
  • electromagnetic field
ばく露時間 120 s
ばく露装置
ばく露の発生源／構造
Additional information The heating pattern was obtained with two antennas curved on the emitting regions and positioned at the proximal end of the personalized vaginal applicator
パラメータ
測定量 値 種別 Method Mass 備考
電力 14 W - - - reflected power 0.1 W

ばく露3

主たる特性
周波数 915–950 MHz
タイプ
  • electromagnetic field
ばく露時間 once a week for a total of 4 sessions, each session lasting 30 min
ばく露装置
ばく露の発生源／構造
Additional information The antenna used was similar to the one described in E2. Hyperthermia was applied to a patient who was suffering from vaginal stump recurrence. The applicator was filled with distilled water and two antennas were inserted in it and bent at the proximal end of the applicator. The desired temperature was 43°C.
パラメータ
測定量 値 種別 Method Mass 備考
電力 14 W - - - reflected power 0.1 W

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

The preliminary data indicate that individualized vaginal applicators might potentially improve the delivery of the therapeutic hyperthermia to malignant lesions located in the apex of the vagina. Further development and characterization of this type of applicator is warranted.

研究の種別:

研究助成