この研究は、脂質過酸化に対するミリ波の影響を、メラニンの存在下および非存在下で調べた。リポソームに、周波数 53.6、61.2および78.2GHz、入射電力密度10、1、500mW / cm2の連続波のミリ波照射を行った実験では、未照射対照群と比較して、照射群で過酸化脂質形成の増加は見られなかった；254nmUVC（0.32mW / cm 2）および302nmUVB（1.12mW / cm2）の照射を受けたリポソームを陽性対照とした；ADP-Fe + 3およびEDTA-Fe + 3の存在下でリポソームへのミリ波照射を行った実験では、脂質過酸化物形成の増加は見られなかった；メラニンへの直接のミリ波照射は、スーパーオキシドまたは過酸化水素の形成の増加を示さなかった；これらの知見は、実験に用いたミリ波がリポソーム膜に脂質過酸化を引き起こさないことを示している、と報告している。
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To study if millimeter wave irradiation would generate reactive oxygen species and cause lipid peroxidation in biological tissue in the presence and absence of melanin.
Liposomes were used as a model for cellular membranes.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
53.62 GHz
ばく露時間:
30 min
|
|
|
ばく露2:
61.2 GHz
ばく露時間:
30 or 60 min
|
|
|
ばく露3:
78.2 GHz
ばく露時間:
30 min
|
For positive control, samples in 3.5 cm Petri dishes were exposed to ultraviolet C radiation UVC (254 nm) and UVB (302 nm) for 15 or 30 min, respectively.
| 周波数 | 53.62 GHz |
|---|---|
| ばく露時間 | 30 min |
| Modulation type | unspecified |
|---|
| ばく露の発生源／構造 | |
|---|---|
| Distance between exposed object and exposure source | 0.006 m |
| チャンバの詳細 | Samples (Liposomes 2 or 6 mg/ml) with or without melanin were exposed at room temperature in 35 mm Petri dishes or in cylindrical plastic vail through a parafilm window. |
| ばく露装置の詳細 | Samples were placed on the top of the horn antenna (10 x 20 mm) |
| Additional information | Control samples were kept in the dark. |
| 周波数 | 61.2 GHz |
|---|---|
| ばく露時間 | 30 or 60 min |
| Modulation type | unspecified |
|---|
| ばく露の発生源／構造 | |
|---|---|
| Distance between exposed object and exposure source | 0.02 m |
| ばく露装置の詳細 | Samples were kept below the horn antenna |
| 周波数 | 78.2 GHz |
|---|---|
| 特性 |
|
| ばく露時間 | 30 min |
| Modulation type | unspecified |
|---|
| ばく露の発生源／構造 |
|
|---|---|
| Distance between exposed object and exposure source | 0.0004 m |
| ばく露装置の詳細 | Waveguide positioned below samples |
The findings show that irradiation of liposomes with electromagnetic waves at frequencies of 53.6, 61.2 and 78.2 GHz (and incident power densities of 10, 1 and 500 mW/cm², respectively), did not enhance the formation of lipid peroxides compared to unexposed samples. No increment in the formation of lipid peroxides was revealed when exposure of liposomes was carried out in the presence of ADP-Fe+3 and EDTA-Fe+3. Irradiation of melanin with millimeter waves did not exhibit an increased formation of superoxide or hydrogen peroxide.
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