ジャンガリアンハムスターから単離した松果腺をメラトニン合成を誘導するため、βアドレナリン作動性受容体作動薬イソプロテレノールで刺激されたクレブス・リンゲル緩衝液によって灌流し、1800MHzの連続波（CW）もしくはSARが8、80、800、2700mW/kgのGSM-変調電磁波へ7時間ばく露した。実験は盲検で行った。灌流サンプルを毎時間回収し、メラトニン濃縮を放射免疫測定によって測った。CWおよびGSM両タイプの信号で、SARが800mW/lkgでメラトニンの放出は有意に高まったが、SARが2700mW/kgでは、CWではメラトニンレベルが上昇したが、GSMでは抑制された。SARが2700mW/kgで、温度が約1.2℃上昇するが、このレベルでの影響は熱的であった。RF電磁界について、非熱的なばく露がメラトニン合成を抑制することから、データは”メラトニン仮説”を裏付けないことがわかる。
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To study the direct effects of high-frequency 1800 MHz electromagnetic fields of different SAR levels on melatonin release by isolated pineal organs from Djungarian hamsters.
Both continuous wave and pulsed wave signals were used. The pulse signals were modulated according to the GSM.
The pineal glands were perifused with a special buffer containing the beta-adrenergic agonist isoproterenol to stimulate melatonin synthesis.
| 周波数 | 1,800 MHz |
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| タイプ |
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| 特性 |
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| ばく露時間 | continuous for 7 h |
| Modulation type | CW |
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| ばく露の発生源／構造 | |
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| チャンバの詳細 | A modified radial waveguide exposure system was used whose principal features have been described in the reference article. Two identical waveguides (diameter 40 cm, height 3 cm) were placed in an incubator at 35 ± 1°C and activated one day prior to each experiment to allow for temperature equilibrium. Every experiment used one unit for exposure and one for sham-exposure controlled (blind randomized) by the data acquisition system. |
| ばく露装置の詳細 | Inside the radial waveguides, which were terminated by thin absorber sheets (< -20 dB at 2 GHz), 20 glass cylinders each containing a pineal gland were arranged at a constant distance from a cone antenna in the center. The flexible tubes of the pumping system were connected to the glass receptacles through circular waveguides beyond cut-off to prevent any RF leakage. Each exposure unit contained one calibrated temperature probe instead of a pineal gland within a glass cylinder. |
| Additional information | Different intensities for SAR values of 8, 80, 800, and 2700 mW/kg were used according to detailed calculations of the absorbed RF-EMF in the pineal gland tissue. The upper limit of 2700 mW/kg SAR was selected because pre-experiments revealed that higher values caused thermal effects (i.e. temperature differences of more than 1°C between exposed and control units). |
| 周波数 | 1,800 MHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | continuous for 7 h |
| Modulation type | pulsed |
|---|---|
| Additional information |
GSM-modulated |
| ばく露の発生源／構造 |
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|---|
Both types of signal significantly enhanced melatonin release at 800 mW/kg, while at 2700 mW/kg melatonin levels were elevated in the continuous wave, but suppressed in the GSM-exposed pineal glands. As a temperature rise of approximately 1.2°C was measured at 2700 mW/kg, effects at this level are thermal.
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