この研究は、ミリ波（MMW）療法が、一般的な抗がん剤であるシクロホスファミド（CPA）の有効性を高めるか否かを調べた。SKH-1無毛雌マウスのメラノーマの成長に対するMMW-CPA併用治療の効果をCPA単独治療と比較した。 MMWはロシア製のYAV-1発生器で発生させた。この装置は10 x 20 mmの長方形のホーンアンテナから42.2±0.2 GHzの変調波を放射した。マウスの鼻領域へ与えた照射のピークSARおよび入射電力密度はそれぞれ、730±100 W / kgおよび36.5±5 mW / cm2と測定された。30分の照射終了時に測定された最大皮膚表面温度上昇は1.5 ℃であった。B16F10メラノーマ細胞（0.2×10（6））は、実験の1日目にマウスの左脇腹に皮下移植された。 同4〜8日目にCPAを腹腔内投与した（30 mg / kg /日）。MMW照射は、CPA投与期間中、同時に行った。また投与期間の前、または後にMMW照射する実験も行った。その結果、CPA単独治療では腫瘍成長の有意な減少が観察された（P <.05）；MMA照射は、CPA単独と比較して追加の治療効果を示さなかった；CPA治療の前後にMMW照射を行った場合も、同様の結果であった、と報告している。
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To study whether millimeter wave therapy can increase the efficacy of cyclophosphamide, a commonly used anti-cancer drug.
B16F10 melanoma cells were implanted subcutaneously into the flank of mice on day 1 of the experiment. On days 4-8, cyclophosphamide was administered.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
42 GHz
ばく露時間:
repeated daily exposure, 30 min/day from day 4 to 8
|
|
|
ばく露2:
42 GHz
ばく露時間:
30 min/day from day 1 to 3 and from day 9 to 11
|
|
|
ばく露3:
42 GHz
ばく露時間:
30 min/day from day 9 to 11
|
|
|
ばく露4:
42 GHz
ばく露時間:
30 min/day from day 1 to 3 and from day 8 to 10
|
| 周波数 | 42 GHz |
|---|---|
| 特性 |
|
| ばく露時間 | repeated daily exposure, 30 min/day from day 4 to 8 |
| Modulation type | cf. additional information |
|---|---|
| Additional information |
Modulated at 60 Hz |
| ばく露の発生源／構造 | |
|---|---|
| Distance between exposed object and exposure source | 0.005 m |
| ばく露装置の詳細 | The animals were restrained in individual centrifuge tubes in a manner that their nose stuck out of the tube in front of the antenna. |
| Sham exposure | A sham exposure was conducted. |
| 周波数 | 42 GHz |
|---|---|
| 特性 |
|
| ばく露時間 | 30 min/day from day 1 to 3 and from day 9 to 11 |
| Additional information | The animals were treated with 30 mg/kg CPA inbetween the two MMW (millimeterwave) exposure. |
| Modulation type | cf. additional information |
|---|---|
| Additional information |
Modulated at 60 Hz |
| ばく露の発生源／構造 |
|
|---|---|
| Distance between exposed object and exposure source | 0.005 m |
| 周波数 | 42 GHz |
|---|---|
| 特性 |
|
| ばく露時間 | 30 min/day from day 9 to 11 |
| Additional information | The animals were treated with 30 mg/kg CPA from day 4 to 8 and then irradiated to MMW. |
| Modulation type | cf. additional information |
|---|---|
| Additional information |
Modulated at 60 Hz |
| ばく露の発生源／構造 |
|
|---|---|
| Distance between exposed object and exposure source | 0.005 m |
| 周波数 | 42 GHz |
|---|---|
| 特性 |
|
| ばく露時間 | 30 min/day from day 1 to 3 and from day 8 to 10 |
| Additional information | The animals were treated with 50 mg/kg CPA on 4 and 11 day and were irradiated to MMW on day 1 to 3 and 8 to 10. |
| Modulation type | cf. additional information |
|---|---|
| Additional information |
Modulated at 60 Hz |
| ばく露の発生源／構造 |
|
|---|---|
| Distance between exposed object and exposure source | 0.005 m |
A significant reduction in tumor growth was revealed with cyclophosphamide treatment, but millimeter wave exposure did not provide additional therapeutic benefit as compared to cyclophosphamide alone. Similar data were obtained when millimeter wave irradiation was applied both prior to and following cyclophosphamide administration.
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