研究のタイプ: 医学／生物学の研究 (experimental study)

[ラットの音への驚愕反応のマイクロ波パルスによる修飾：予備的報告] med./bio.

Modification of acoustic startle by microwave pulses in the rat: a preliminary report

著者: Seaman RL, Beblo DA
掲載誌: Bioelectromagnetics 1992; 13 (4): 323-328
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この研究は、4匹のラットを用い、個体ごとに、単一の1.25GHzマイクロ波パルス（パルス幅0.8-1.0マイクロ秒）を、驚愕誘発性音響刺激提示の100ms前に提示する実験を行った。その結果、マイクロ波パルスと音響刺激の連続対が驚愕反応を変化させることが観察された；頭部の1パルス当たりのエネルギー量が22-43mJ / kg（ピークSARは23-48kW / kg）では、対照（音響刺激だけで起こった反応）に比べ、驚愕反応までの平均潜時が長くなり、応答の平均振幅は小さくなった； 頭部の1パルス当たりのエネルギー量が59-107mJ / kg（ピークSARは63-111kW / kg）と高くなると、驚愕反応の平均潜時および振幅は、対照での反応のそれぞれの平均値と統計的に差がなかった、と報告している。

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研究目的（著者による）

Single, 1.25-GHz microwave pulses of 0.8- to 1.0 µs duration were presented to rats 100 ms before presentation of a startle-inducing acoustic stimulus. This sequential pairing of microwave pulse and acoustic stimulus was found to change the startle response. The purpose of the study was to validate methodology for future investigations.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1.25 GHz
Modulation type: single pulse
  • 電力: 5.2 kW peak (1.1-5.2 kW)
  • SAR: 48 kW/kg peak (brain) (23-48 kW/kg)
  • SA: 43 mWs/kg peak (brain) (22-43 mWs/kg)
  • SAR: 111 kW/kg peak (brain) (63-111 kW/kg)
  • SA: 107 mWs/kg peak (brain) (59-107 mWs/kg)

ばく露1

主たる特性
周波数 1.25 GHz
タイプ
  • electromagnetic field
特性
  • guided field
Modulation
Modulation type single pulse
Pulse width 1 µs
Additional information

Pulse durations were between 0.8 and 1.0 µs.
ばく露装置
ばく露の発生源／構造
チャンバの詳細 sound attenuating chamber
ばく露装置の詳細 The exposure device was a downward-pointing WR-650 waveguide with a shorted end plane and a hole in one of the wider walls. The rat was placed in a ventilated plastic cylinder one end of which was moved through the hole to position the animal's head inside the waveguide.
Additional information A single pulse was delivered 100 ms before the onset of the startle-inducing acoustic stimulus.
パラメータ
測定量 値 種別 Method Mass 備考
電力 5.2 kW peak 測定値 - 1.1-5.2 kW
SAR 48 kW/kg peak 測定値 brain 23-48 kW/kg
SA 43 mWs/kg peak 測定値 brain 22-43 mWs/kg
SAR 111 kW/kg peak 測定値 brain 63-111 kW/kg
SA 107 mWs/kg peak 測定値 brain 59-107 mWs/kg
測定および計算の詳細

Directional couplers were used for monitoring forward and reflected powers. Head SARs depending on body mass were determined by thermometric measurements during CW irradiation of cadavers.

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 感覚器
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

At an energy dose to the head of 22-43 mWs/kg per pulse (peak SAR, 23-48 kW/kg), the mean latency to the startle response was longer and the mean amplitude of the response was smaller with respect to control responses that occured to acoustic stimuli alone. However, at a higher energy dose per microwave pulse (59-107 mWs/kg; peak SAR, 63-111 kW/kg), the mean latency and amplitude of the startle response were not statistically different from the respective mean of control responses.

研究の種別:

研究助成