研究のタイプ: 医学／生物学の研究 (experimental study)

[9.3 GHz無線周波放射にばく露したラットの体温調節反応] med./bio.

Thermoregulatory responses of rats exposed to 9.3-GHz radiofrequency radiation

著者: Frei MR, Jauchem JR, Heinmets F
掲載誌: Radiat Environ Biophys 1989; 28 (1): 67-77
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この研究は、ケタミンで麻酔したSprague-DawleyラットにH方向の遠方界9.3GHz電磁界（平均電力密度30および60mW / cm 2、連続波（CW）またはパルス変調波（パルス幅2μ秒、500pps））の全身ばく露を与え、その影響を調べた。それぞれの電力密度における全身平均SARは9.3および18.6W / kgであった。結腸温度を38.5℃から39.5℃まで上昇させるようにばく露が行われた。ばく露中、結腸、鼓膜、および皮下の温度、ECG、血圧、および呼吸数を連続的に記録した。その結果、２つの電力密度において、皮下および鼓室の温度上昇は、結腸温度の上昇を有意に上回った；２つの電力密度のばく露中、心拍数が有意に上昇し、ばく露が停止されるとベースラインに戻った；ばく露中に血圧および呼吸数は有意に変化しなかった；CWとパルス波のばく露の影響に有意差はなかった、と報告している。

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研究目的（著者による）

To compare the acute effects of continuous wave and pulsed 9.3 GHz radiofrequency irradiation upon the thermoregulatory responses and related physiological processes in anesthetized rats.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 9.3 GHz
Modulation type: pulsed
ばく露時間: intermittent*
  • 電力密度: 600 W/m² mean (18.6 W/kg corresponding average whole body SAR)
  • 電力密度: 300 W/m² mean (9.3 W/kg corresponding average whole body SAR)
ばく露2: 9.3 GHz
Modulation type: CW
ばく露時間: intermittent*
  • 電力密度: 300 W/m² mean (9.3 W/kg corresponding average whole body SAR)
  • 電力密度: 600 W/m² mean (18.6 W/kg corresponding average whole body SAR)

General information

*The exposure was discontinued when the colonic temperature increased to 39.5?C and it was initiated again when the temperature returned to 38.5?C. This procedure was continued for 8 cycles.

ばく露1

主たる特性
周波数 9.3 GHz
特性
  • far field
偏波
  • linear
ばく露時間 intermittent*
Additional information Animals wre exposed in H-orientation (long axis parallel to magnetic field)
Modulation
Modulation type pulsed
Pulse width 2 µs
Repetition frequency 500 Hz
ばく露装置
ばく露の発生源／構造
Distance between exposed object and exposure source 1.5 m
チャンバの詳細 Eccosorb RF-shielded anechoic chamber maintained at 24?C and 50% humidity
ばく露装置の詳細 Rats placed on a holder.
Additional information The holder consisted of seven 0.5 cm (O.D) Plexiglas rods mounted in a semicircular pattern on 4 cm x 6 cm Plexiglas plates (0.5 cm thick).
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 600 W/m² mean 測定値 - 18.6 W/kg corresponding average whole body SAR
電力密度 300 W/m² mean 測定値 - 9.3 W/kg corresponding average whole body SAR

ばく露2

主たる特性
周波数 9.3 GHz
特性
  • far field
偏波
  • linear
ばく露時間 intermittent*
Additional information Animals were exposed in H.orienation (long axis parallel to magnetic field)
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Distance between exposed object and exposure source 1.5 m
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 300 W/m² mean 測定値 - 9.3 W/kg corresponding average whole body SAR
電力密度 600 W/m² mean 測定値 - 18.6 W/kg corresponding average whole body SAR

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中

研究の主なアウトカム（著者による）

There were no significant differences between the effects of continuous wave and pulsed wave exposure. At both power densities, the subcutaneous and tympanic temperature increases significantly exceeded the colonic temperature increase. At both irradiation levels, heart rate increased significantly and returned to baseline when exposure was discontinued. Blood pressure and respiratory rate did not significantly change during exposure.
The levels of subcutaneous heating and heart rate change were greater, and the times required to achieve and to recover from a 1°C colonic temperature increase were longer than in previous investigations conducted at 2.8 GHz (e.g. publication 9288). Data of these studies suggest that the carrier frequency used during irradiation markedly affects the pattern of heat distribution and the physiological responses of radiofrequency-irradiated rats.

研究の種別:

研究助成

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