研究のタイプ: 医学／生物学の研究 (experimental study)

[2.45 GHzの無線周波放射にばく露したラットの熱反応および生理的反応：EおよびHの向きの比較] med./bio.

Thermal and physiological responses of rats exposed to 2.45-GHz radiofrequency radiation: a comparison of E and H orientation

著者: Frei MR, Jauchem JR, Padilla JM, Merritt JH
掲載誌: Radiat Environ Biophys 1989; 28 (3): 235-246
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この研究は、ケタミンで麻酔したSprague-Dawleyラットを、EおよびH方向に向けて、遠方界の2.45GHz連続波電磁界放射（RFR：60mW / cm 2）のばく露を与えた。全身平均SARは約14 W / kgであった。両方向での断続的なばく露を同じ動物で行って、反復的に結腸温度を38.5℃から39.5℃まで上昇させた。鼓膜、皮下（RFR源に近い側および遠い側）、結腸温度、ECG、動脈圧および呼吸数を連続的に記録した。その結果、動物内の熱分布のパターンおよび生理学的応答は、EおよびH方向でのばく露によって有意に異なっていた；心拍数および血圧は、ばく露中に有意に増加し、ばく露が中止されるとベースラインレベルに戻った；増加はH方向よりもE方向において有意に大きかった；呼吸数は、H方向では有意に増加したが、E方向では増加しなかった、と報告している。

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研究目的（著者による）

To compare the effects of acute exposure to 2.45 GHz radiofrequency irradiation in E-orientation (long axis of body parallel to electric field) and H-orientation (long axis of body parallel to magnetic field) upon the patterns of heat distribution, the overall heating and cooling responses, and changes in cardiovascular and respiratory function in anesthetized rats.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: CW
ばく露時間: intermittent*
  • 電力密度: 600 W/m² mean (corresponding whole body average SAR was 14.5 ± 2.2 W/kg)
ばく露2: 2.45 GHz
Modulation type: CW
ばく露時間: intermittent*
  • 電力密度: 600 W/m² mean (corresponding whole body average SAR was 12.4 ± 2.6 W/kg)

General information

*The exposure was discontinued when the colonic temperature increased to 39.5°C and it was initiated again when the temperature returned to 38.5°C. This procedure was continued for 3 cycles

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
特性
  • far field
偏波
  • linear
ばく露時間 intermittent*
Additional information Animals were exposed in E orientation (long axis of their body parallel electric field)
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
Distance between exposed object and exposure source 0.0015 m
チャンバの詳細 Eccosorb RF-shielded anechoic chamber
ばく露装置の詳細 Rats placed on a holder
Additional information The rise time and the recovery time were 8.6 ± 0.4 and 16.6 ± 1.3 min respectively The holder consisted of seven 0.5 cm (O.D) Plexiglas rods mounted in a semicircular pattern on 4 cm x 6 cm Plexiglas plates (0.5 cm thick)
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 600 W/m² mean 測定値 - corresponding whole body average SAR was 14.5 ± 2.2 W/kg
Additional parameter details

Normalized SAR determined calorimetrically was 0.24 (W/kg)/(mW/cm²)

ばく露2

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
特性
  • far field
偏波
  • linear
ばく露時間 intermittent*
Additional information Animals exposed in H orientation (magnetic field parallel to the long axis of the animal)
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
Distance between exposed object and exposure source 0.0015 m
チャンバの詳細 Eccosorb RF-shielded anechoic chamber
ばく露装置の詳細 Rats placed on a holder
Additional information The rise time and the recovery time were 8.0 ± 0.2 and 15.2 ± 1.1 min respectively The holder consisted of seven 0.5 cm (O.D) Plexiglas rods mounted in a semicircular pattern on 4 cm x 6 cm Plexiglas plates (0.5 cm thick)
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 600 W/m² mean 測定値 - corresponding whole body average SAR was 12.4 ± 2.6 W/kg
Additional parameter details

Normalized SAR determined calorimetrically was 0.21 (W/kg)/(mW/cm²)

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中

研究の主なアウトカム（著者による）

The pattern of heat distribution within the rat and the physiological responses were significantly different between E- and H-orientation irradiation. Exposure in E-orientation resulted in greater peripheral and tympanic heating, while exposure in H-orientation resulted in greater body core heating.
Heart rate and blood pressure increased significantly during exposure and returned to baseline levels when irradiation was discontinued; the increases were significantly greater in E- than in H-orientation. Respiratory rate increased significantly during exposure in H-, but not in E-orientation.
The physiological responses could have been influenced by the different levels or rates of subcutaneous and tympanic heating, or the differential between body core and peripheral heating during E- and H-orientation exposure.

研究の種別:

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