研究のタイプ: 医学／生物学の研究 (experimental study)

[心臓活動に対するパルス化マイクロ波の影響の分析] med./bio.

Analysis of the effects of pulsed microwaves on cardiac activity

著者: Tamburello CC, Tine G, Zanforlin L
掲載誌: Bioelectrochem Bioenerg 1993; 30: 303-311
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この研究は、単離したニワトリ胚心臓に2.45GHzパルス変調マイクロ波のばく露を与え、その影響を調べた。その結果、（1）心拍が不規則な場合、適切なパルス反復率により規則化される、（2）心拍が規則的な場合、パルス繰返し率上昇とともに心拍数が上昇し、それは不規則拍動が現れるまで続く、（3）不整脈が発生した場合、マイクロ波ばく露により、その数秒後に規則的拍動が現れる、という知見が得られたと報告している。心拍と変調パルスとの時間相関を調べ、自然な心拍に近い周波数の変調パルスが心室拡張期に与えられた場合に、規則化が生じることが示されたという。

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研究目的(acc. to editor)

This study was conducted to evaluate the effects of pulsed microwaves exposure on isolated hearts of chicken embryos for two different physiological conditions: regular and irregular heartbeat.

詳細情報

The experiments were carried out on isolated living hearts of 8-9 days old chicken embryos.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: pulsed
ばく露時間: repeated exposures in the order of 1 min

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
ばく露時間 repeated exposures in the order of 1 min
Modulation
Modulation type pulsed
Duty cycle 10 %
Additional information

pulse rates of 1-3 Hz
ばく露装置
ばく露の発生源／構造
  • coaxial MW radiator
チャンバの詳細 A pre-oxygenated avian Ringer's solution kept at 37°C was perfused in the sample holder.
ばく露装置の詳細 The heart was placed in the sample holder with its main axis perpendicular to the EF in the max. field area and irradiated from the bottom by a tapered open coaxial section.
Additional information In cases of regular heartbeat, the MW pulse rate was set a little higher than the unperturbed natural heart rate. In cases of arrhythmia, a constant pulse rate was selected within physiological limits (1-3 Hz). Usually, the beating heart allowed to conduct tests for about 6 h.
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 3 mW/cm² peak - - -

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

An appropriate pulse repetition rate caused regularization of irregular heartbeat. During regular heartbeat, an increase of pulse repetition rate similarly increased the heartbeat frequency, until an irregular heartbeat appeared. By applying microwaves, when an arrhythmia occured, a regular heartbeat appeared after a few seconds.
These results suggest a mechanism for the synchronization effect induced by pulse-modulated microwaves on heart cells.

研究の種別:

研究助成

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