この研究は、雌のC3H / Biマウス（肺転移性を持つ、自然発生性でウイルス性の乳がんを発症する）の担がんマウス（n = 240）をばく露群と対照群に分け、ばく露群は、トロイダルパルス磁界（12Hz、100Hzまたは460Hz）のばく露を、10分間／日で3日／週、または1週間に1回30分間のばく露スケジュールで、がん出現の２−３週後から死亡するまで継続した。その結果、対照群と比較して、ばく露群の脾臓および肺の重量は少なかった；肺が軽量であることは肺転移の減少を意味するかもしれない；腫瘍の重量は、対照群に比べ、460Hz MF群では軽く、100Hz群では変化なく、12Hz群では重かったが、MFばく露によって寿命は変化しなかった、と報告している。
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To investigate the effects of 3 different pulsed magnetic fields (PMF) on tumoral mice.
A total of 240 mice were used in this study. 98 mice served as control. 75 mice were exposed to 460 Hz PMF, 35 mice to 100 Hz, and 32 mice to 12 Hz.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
12 Hz
Modulation type:
pulsed
ばく露時間:
from appearance of Tumor till death; 30 min/week or 10 min on 3 non-consecutive days of the week
|
|
|
ばく露2:
100 Hz
Modulation type:
pulsed
ばく露時間:
from appearance of Tumor till death; 30 min/week, 10 min on 3 non-consecutive days of the week or 30 min/day, 3 days per week
|
|
|
ばく露3:
460 Hz
Modulation type:
pulsed
ばく露時間:
from appearance of Tumor till death; 30 min/week; 10 min on 3 non-consecutive days of the week; 30 min/day, 3 days per week; 15 min, 2 days a week; 6 min 5 days a week; 30 min, 2 or 5 days a week
|
|
89 mice were used as control, 75 were exposed to 460 Hz MF, 35 to 100 Hz MF and 32 to 12 Hz.
| 周波数 | 12 Hz |
|---|---|
| タイプ |
|
| 波形 |
|
| ばく露時間 | from appearance of Tumor till death; 30 min/week or 10 min on 3 non-consecutive days of the week |
| Modulation type | pulsed |
|---|---|
| Additional information |
Toroidal pulsed magnetic field |
| ばく露の発生源／構造 |
|
|---|---|
| チャンバの詳細 | Exposure was performed in a container which was divided into compartments (29 mm x 29 mm x 100 mm); each compartment held one mouse. The applicators were placed on the top of the container exposing 10 mice at a time. Control mice were placed in the container in the same way as the exposed mice but in the absense of magnetic field. |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 6 mT | unspecified | 指定なし | - | - |
| 周波数 | 100 Hz |
|---|---|
| タイプ |
|
| 波形 |
|
| ばく露時間 | from appearance of Tumor till death; 30 min/week, 10 min on 3 non-consecutive days of the week or 30 min/day, 3 days per week |
| Modulation type | pulsed |
|---|---|
| Additional information |
Toroidal pulsed magnetic field |
| ばく露の発生源／構造 |
|
|---|
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 6 mT | unspecified | 指定なし | - | - |
| 周波数 | 460 Hz |
|---|---|
| タイプ |
|
| 波形 |
|
| ばく露時間 | from appearance of Tumor till death; 30 min/week; 10 min on 3 non-consecutive days of the week; 30 min/day, 3 days per week; 15 min, 2 days a week; 6 min 5 days a week; 30 min, 2 or 5 days a week |
| Modulation type | pulsed |
|---|---|
| Additional information |
Toroidal pulsed magnetic field |
| ばく露の発生源／構造 |
|
|---|
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 6 mT | unspecified | 指定なし | - | - |
No differences of mean life span were found between the groups. Mean tumor weight were found to be lighter in mice exposed to 460 Hz and higher in mice exposed to 12 Hz as compared with control. The exposed mice showed lighter lungs and spleens, compared with the control group.
The data may indicate a window frequency effect or suggest that higher frequencies inhibit growth.
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