研究のタイプ: 医学／生物学の研究 (experimental study)

[培養条件下での眼球レンズに対するマイクロ波の局所効果] med./bio.

Localized effects of microwave radiation on the intact eye lens in culture conditions

著者: Dovrat A, Berenson R, Bormusov E, Lahav A, Lustman T, Sharon N, Schachter L
掲載誌: Bioelectromagnetics 2005; 26 (5): 398-405
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この研究は、培養中のウシの眼の水晶体に対するマイクロ波放射の局所的な影響を2週間にわたって調べた。その結果、マイクロ波放射が眼の水晶体に与えた影響を巨視的レベルで観察すると、1 GHzで数mWに36時間以上ばく露すると、水晶体の光学機能に影響することが明らかになった；ばく露が中断されれば、自己回復が確認された；水晶体を精密に検査すると、顕微鏡レベルの相互作用メカニズムは、温度上昇を経て白内障が発生するメカニズムとは完全に異なることが示された；後者の効果とは反対に、それは水晶体縫合線の周辺で特に顕著であり、レンズを構成する線維の端部間の局所的摩擦の結果であると想定された；たとえ巨視的には水晶体が照射から回復したとしても、もしかしたら微視的には照射の影響の徴候は残るかもしれない、と報告している。

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研究目的（著者による）

A novel experimental system was used to study the localized effects of microwave irradiation on eye lenses in culture for over 2 weeks. The purpose of the study was to focus on effects that are not caused by global temperature increase (temperature is maintained constant at 35°C).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1.1 GHz
Modulation type: CW
ばく露時間: intermittent, 50 min on/10 min off, for 8 days (192 cycles)

ばく露1

主たる特性
周波数 1.1 GHz
タイプ
  • electromagnetic field
特性
  • guided field
ばく露時間 intermittent, 50 min on/10 min off, for 8 days (192 cycles)
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
チャンバの詳細 The exposure system consisting of four transmission lines was placed in an incubator maintained at 35°C.
ばく露装置の詳細 Each lens was placed in a vessel and completely immersed in tissue culture medium. The vessel was inserted between the two metallic plates forming the transmission line that were of the same width as their separation. The medium filled the vessel up to the height of the plates. The configuration was designed to maximize both the uniformity and the intensity of the field in the lens region (11-12 mm height and 15-16 mm diameter).
Additional information Four lenses were exposed simultaneously while four control lenses were kept in another incubator at the same temperature for the same period of time without any exposure to MW radiation.
パラメータ
測定量 値 種別 Method Mass 備考
電力 2.2 mW - 測定値 - -
電力密度 0.1 kW/m² - 測定値 - -
SAR 1.4 W/kg maximum 電力損失による決定値 - -
測定および計算の詳細

The power at the termination of the transmission line was measured (1) with the vessel in place filled with medium but without the lens, and (2) with a metallic coin of the size of a lens placed at the exact location of the lens. The difference is the upper limit of what the lens may absorb. Calibration with the lens in place was performed, too.

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 感覚器
  • eye
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

The authors found clear evidence that this irradiation has a significant impact on the eye lens. At the macroscopic level, it is revealed that exposure to a few mW at 1 GHz for over 36 h affects the optical function of the lens. Self-recovery occurs if the irradiation is interrupted.
At the microscopic level, close examination of the lens indicates that the interaction mechanism is completely different from the mechanism-causing cataract via temperature increase. Even if macroscopically the lens has recovered from the exposure, microscopically the indicators of irradiation impact remain.

研究の種別:

研究助成

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