研究のタイプ: 医学／生物学の研究 (experimental study)

[男女患者の筋肉痛に低周波電磁界の治療効果はさまざまである] med. app.

Low frequency therapeutic EMF differently influences experimental muscle pain in female and male subjects

著者: Lyskov E, Kalezic N, Markov M, Hansson Mild K, Thunberg J, Johansson H
掲載誌: Bioelectromagnetics 2005; 26 (4): 299-304
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この研究は、疼痛治療用機器MD TEMF（EMF Therapeutics、Inc.、Chattanooga）の発生する脈動性半正弦波磁界（MF：パルス周波数100 Hz、磁束密度15 mT rms）を用いた処置における主観的疼痛評点、心拍数、動脈血圧について、筋肉痛を実験的に与えた24人の健康なボランティア（12人の女性と12人の男性、平均年齢24.7±3.2歳）用いた二重ブラインド化クロスオーバーデザインで試験した。被験者それぞれは、真の処置および擬似処置のセッション中、脊柱起立筋への5 %の高張食塩水（HS）注入による痛み刺激を受けた。その結果、MFばく露は、女性および男性の主観的痛み推定値に異なる影響を与えた；MFばく露は、女性の平均疼痛レベルおよび疼痛評点の時間積分値を増加させたが、男性ではこれらの特性においてMFばく露による有意差は見られなかった；女性および男性の被験者で、真の処置および擬似処置のセッション中に、痛みに随伴した収縮期および拡張期血圧の上昇が観察された、と報告している。

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研究目的（著者による）

To investigate the effects of a low frequency therapeutic magnetic field on subjective pain rating, heart rate, and arterial blood pressure employing experimental muscle pain.

詳細情報

Twelve female and twelve male healthy volunteers participated in this study where each subject served as his/her own control. Muscle pain was induced by intramuscular injection of 5% hypertonic saline into the right erector mucle of the spine.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 100 Hz
ばく露時間: 20 min
pulsating half sine wave
  • 磁束密度: 3.4 mT effective value (at a distance of 30 cm from the coil)
  • 磁束密度: 15 mT effective value (at the center of the coil)
  • 磁束密度: 6.4 mT effective value (at a distance of 20 cm from the coil)
  • 磁束密度: 1.9 mT effective value (at a distance of 40 cm from the coil)

ばく露1

主たる特性
周波数 100 Hz
タイプ
  • magnetic field
ばく露時間 20 min
Additional information pulsating half sine wave
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 the coil was placed around the body at the L3 vertebral level where the catheter was located
Sham exposure A sham exposure was conducted.
Additional information During the exposure as well as sham exposure, muscle pain was induced by intramuscular injection of hypertonic saline (HS) by an infusion pump connected to the catheter via plastic extension tube. HS was injected into the right erector spinae muscle at the level of L3 spinous process. The muscle pain was induced twice in two separate sessions with at least 2 days interval between them. One session was accompanied by exposure and the other was conducted under sham exposure.
パラメータ
測定量 値 種別 Method Mass 備考
磁束密度 3.4 mT effective value 計算値 - at a distance of 30 cm from the coil
磁束密度 15 mT effective value 指定なし - at the center of the coil
磁束密度 6.4 mT effective value 計算値 - at a distance of 20 cm from the coil
磁束密度 1.9 mT effective value 計算値 - at a distance of 40 cm from the coil

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

Exposure to magnetic field differently affected subjective pain estimates in females and males. Exposure to magnetic field increased averaged pain level and time integral of pain ratings in females, whereas no statistically significant difference was observed in males. Pain related elevation of systolic and diastolic blood pressure was found during both real and sham exposure in both genders.

研究の種別:

研究助成