この研究は、ラットに、出生の2日前から出生後7日目まで、強度がnT範囲またはμT範囲の0.5 Hz方形波パルス磁界への連続的ばく露を与え、その影響を調べた。磁界は、東西（E-W）または南北（N-S）方向のどちらかで発生させた。その結果、21日齢で、nT範囲の東西方向、あるいはμT範囲の東西または南北方向の磁界ばく露群において、nT範囲の南北方向磁界ばく露群に比べ、延髄の傍孤束核の面積が著しく小さく、ニューロンの数が少なかった；これらの知見は、特定の方向のnT磁界が地域的地磁気と相互作用して、脳幹内構造での細胞移動に影響する可能性を示唆する、と報告している。
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To investigate the effects of magnetic field exposure on neuron development in rat brain.
Rats were continously exposed to pulsed magnetic fields from two days before birth to one week after birth. At three weeks of age tissue slices of a special part of the brain (the parasolitary nucleus) were investigated.
| 周波数 | 500 mHz |
|---|---|
| タイプ |
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| 波形 |
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| ばく露時間 | continuous for 9 days ( 2 days befor and 7 days after birth) |
| Modulation type | pulsed |
|---|---|
| Pulse width | 600 ms |
| Pulse type | rectangular |
| Additional information |
wave onset (transient spike) with a rise time between 1.5 and 3.5 µs and offset (similar spike) with opposite polarity |
| ばく露の発生源／構造 | |
|---|---|
| ばく露装置の詳細 | two aluminum racks seperated by 2 m and arranged in either east-west or north-south direction, wrapped with 72 turns of 30-gauge copper wire Rats were exposed in plastic cages where the magnetic field was perpendicular to the horizontal plane. |
| Additional information | The amplitude of the magnetic fields changed every 30 min and were applied in the following order: 870 nT, 1.04 µT, 1.3 µT, 1.77 µT, 1.33 µT, 1.04 µT and 8 nT. This order was called one cycle and each day such six cycles were applied. |
The parasolitary nucleus was found to be significantly smaller, and the number of neurones were significantly reduced in exposed rats. The results of this study suggest that magnetic fields, when applied in a nano-Tesla range and in a specific direction, might interact with the local geomagnetic field to affect cell structures in the rat brain.
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