The effects of exposure of mouse hippocampal neurons to combined 837 MHz and 1950 MHz electromagnetic fields on beta-amyloid protein-induced cytotoxicity should be investigated.
Few previous animal studies suggested beneficial effect of radiofrequency fields in Alzheimer's disease (Arendash et al. 2010, Banaceur et al. 2013). In contrast, EMF exposure was also found to increase beta-amyloid protein expression (Jiang et al. 2013). The present study should elucidate the possible mechanism of action in vitro.
Cells were divided into the following groups: 1) exposure to the electromagnetic fields only, 2) exposure to the electromagnetic fields and treatment with 5 µM beta-amyloid protein, 3) exposure to the electromagnetic fields and treatment with 50 µM beta-amyloid protein. For each group, a separate sham exposure group was used.
cells were treated with respective concentrations of beta-amyloid protein (5 µM and 50 µM) for 30 minutes prior to exposure to the electromagnetic fields
| Frequency | 837–1,950 MHz |
|---|---|
| Type | |
| Exposure duration | continuous for 2 hours |
| Exposure source |
|
|---|---|
| Distance between exposed object and exposure source | 13.6 cm |
| Chamber | 100 mm petri dishes in exposure chamber with 37 ± 0.3°C and a 5% CO2 |
| Setup | radial transmission line (RTL) exposure system with conical antenna, which was located in the center of the exposure chamber; petri dishes were placed at 13.6 cm from the antenna |
| Sham exposure | A sham exposure was conducted. |
Exposure to the electromagnetic fields had no significant effect on any parameter in any group compared to the respective sham exposure groups.
The authors conclude that exposure of mouse hippocampal neurons to combined 837 MHz and 1950 MHz electromagnetic fields has no effects on the beta-amyloid protein-induced cytotoxicity.
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