This study investigated whether expression of genes related to cell death signal pathways are altered in murine brain cells by the exposure to a working Global System for Mobile Communication cell phone in vitro.
Exposure | Parameters |
---|---|
Exposure 1:
1,900 MHz
Modulation type:
pulsed
Exposure duration:
continuous for 2 h
|
- |
Frequency | 1,900 MHz |
---|---|
Type | |
Exposure duration | continuous for 2 h |
Exposure source | |
---|---|
Setup | Cell cultures were plated in 2 ml of medium with 4 mm depth in 35-mm Petri dishes. For exposure, a mobile phone was placed on top with its antenna over the center and the cover of the dish removed. |
Sham exposure | A sham exposure was conducted. |
Additional info | The phone was either on (exposed) or standby (sham). |
No parameters are specified for this exposure.
The exposure to radiofrequency irradiation from a cell phone leaded to up-regulation of eight genes (amongst others caspase-2, caspase-6) in both "on" and "stand-by" modes in neurons, but only in "on" mode in astrocytes. Additionally, astrocytes showed up-regulation of the bax gene, a gene which regulates signal transduction on mitochondrial level.
These data indicate that even short-term exposure to cell phone radiofrequency emissions can up-regulate elements of apoptotic signal pathways in cells derived from the brain, and that neurons seem to be more sensitive to this effect than astrocytes.
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