To study the effect of 1763 MHz radiofrequency exposure on cultured human dermal papilla cells by evaluating changes in the expression of cytokines related to hair growth.
Additional cell lines were used for comparison.
| Frequency | 1,763 MHz |
|---|---|
| Type | |
| Exposure duration | continuous for 1 h or 3 h |
| Additional info | in vitro |
| Exposure source |
|
|---|---|
| Setup | rectangular cavity-type chamber in TE102 mode; monopole antenna positioned at λ/8 position at the cavity's top plate; cells placed at λ/4 position in the chamber in 100 mm-dishes with a layer thickness of 4 mm; chamber equipped with a cooling device |
| Sham exposure | A sham exposure was conducted. |
| Frequency | 1,763 MHz |
|---|---|
| Type | |
| Exposure duration | continuous for 1 h/day for 7 days |
| Additional info | ex vivo |
| Exposure source |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| SAR | 10 W/kg | - | - | - | - |
The expression of insulin-like growth factor-1 (IGF-1) mRNA in human dermal papilla cells was significantly induced upon radiofrequency exposure (at a SAR value of 10 W/kg), which resulted in increased expression of Bcl-2 and cyclin proteins and increased phosphorylation of the MAPK-1 protein. However, the expression of other growth factors (VEGF, HGF and TGF-beta1) was not changed.
Exposure to 10 W/kg radiofrequency irradiation 1 h per day for 7 days significantly enhanced hair shaft elongation in ex vivo hair organ cultures. In exposed follicular matrix keratinocytes in the hair bulb, the expression of Ki-67 antigen was increased, while the TUNEL-positive cells were decreased.
The authors suggest that 1763 MHz radiofrequency exposure stimulates hair growth in vitro through the induction of IGF-1 in human dermal papilla cells.
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