Involvement of the EGF Receptor in MAPK Signaling Activation by a 50 Hz Magnetic Field in Human Neuroblastoma Cells med./bio.

Aim of study (acc. to author)

Background/further details

Endpoint

• cell viability/cell division/proliferation: cell proliferation and involvement of EGFR

Exposure

• • 50/60 Hz
  • magnetic field

Extended view Compact view

Methods Endpoint/measurement parameters/methodology

• cell viability/cell division/proliferation: cell proliferation (only group 6; trypan blue stain, microscopy)
• molecular biosynthesis: activation of signal pathway proteins (only groups 1-5): protein expression of p-EGFR, p-ERK1/2, p-p38 MAPK and matrix metallopeptidase 9 (MMP-9) (immunofluorescence microscopy and Western blot) and p-SAPK/JNK (Western blot only)

Main outcome of study (acc. to author)

Study funded by

• European Defence Agency (EDA)
• European Union (EU)/European Commission
• Ministerio de Defensa de Espana (Ministry of Defence, Spain)

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