The effects of exposure of rats to a 2100 MHz electromagnetic field on oxidative stress and DNA damage in the brain should be investigated.
Female rats were divided into the following groups: 1) exposure to the electromagnetic field for 2 weeks (n=9), 2) sham exposure for 2 weeks (n=6), 3) exposure to the electromagnetic field for 8 weeks (n=9), 4) sham exposure for 8 weeks (n=6). Two days after the last respective (sham) exposure, the rats were anesthetized, killed and examined.
Exposure | Parameters |
---|---|
Exposure 1:
2,100 MHz
Exposure duration:
6 h/day on 5 consecutive days/week for 2 weeks
|
|
Exposure 2:
2,100 MHz
Exposure duration:
6 h/day on 5 consecutive days/week for 8 weeks
|
|
Frequency | 2,100 MHz |
---|---|
Type | |
Charakteristic | |
Exposure duration | 6 h/day on 5 consecutive days/week for 2 weeks |
Additional info | acute exposure |
Exposure source | |
---|---|
Distance between exposed object and exposure source | 12 cm |
Chamber | plexiglass cage (40 x 25 x 20 cm) in a temperature-controlled and shielded room |
Setup | signal generator was connected to horn antenna placed at a distance of 12 cm to rats' heads; direction of the field propagation was perpendicular to the plexiglass cage |
Sham exposure | A sham exposure was conducted. |
Additional info | sham exposure was conducted in an inactive exposure set-up |
Measurand | Value | Type | Method | Mass | Remarks |
---|---|---|---|---|---|
electric field strength | 16 V/m | - | measured | - | - |
SAR | 0.4 W/kg | - | calculated | whole body | obtained via Finite Difference Time Domain method |
Frequency | 2,100 MHz |
---|---|
Type | |
Charakteristic | |
Exposure duration | 6 h/day on 5 consecutive days/week for 8 weeks |
Additional info | chronic exposure |
Exposure source |
|
---|---|
Sham exposure | A sham exposure was conducted. |
Measurand | Value | Type | Method | Mass | Remarks |
---|---|---|---|---|---|
electric field strength | 16 V/m | - | measured | - | - |
SAR | 0.4 W/kg | - | calculated | whole body | obtained via Finite Difference Time Domain method |
The amount of oxidative DNA damage was significantly increased after two weeks of exposure (group 1) compared to the control group (group 2), whereas no differences were found in lipid peroxidation.
After 8 weeks of exposure (group 3), oxidative DNA damage as well as lipid peroxidation were significantly reduced compared to the control group (group 4).
The authors conclude that an acute exposure of rats to a 2100 MHz electromagnetic field could cause oxidative DNA damage in the brain. However, chronic exposure could also lead to the adaptation and stimulation of DNA repair mechanisms.
This website uses cookies to provide you the best browsing experience. By continuing to use this website you accept our use of cookies.