8-oxoG DNA Glycosylase-1 Inhibition Sensitizes Neuro-2a Cells to Oxidative DNA Base Damage Induced by 900 MHz Radiofrequency Electromagnetic Radiation med./bio.

Aim of study (acc. to author)

Background/further details

Endpoint

• DNA damage, oxidative stress and cell viability

Exposure

• • 900 MHz
• • mobile communications
  • mobile phone
  • GSM
• • co-exposure

Extended view Compact view

Methods Endpoint/measurement parameters/methodology

• genotoxicity/mutation: DNA single-strand breaks and double-strand breaks (alkaline comet assay) and DNA base damage (FPG-modified alkaline comet assay) (only with groups 2 and 3)
• cell viability/cell division/proliferation: cell viability (with all groups; CCK-8 assay, spectrophotometry)
• intracellular level of reactive oxygen species (with all groups without oxoguanine glycosylase silencing; dichlorofluorescein stain, spectrophotometry)

Main outcome of study (acc. to author)

Study funded by

• National Basic Research Program (Program 973), China
• National Natural Science Foundation (NSFC), China

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