To study the effects of extremely low frequency electromagnetic fields and antioxidant supplementation (melatonin, 10-3, 10-4 and 10-5 M; 24 h or 72 h), alone or in combination, on antioxidant enzyme activities and on the level of lipid peroxidation in a carcinoma cell line in vitro.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
3 Hz–3 kHz
Exposure duration:
continuous for 16 min
|
|
| Frequency | 3 Hz–3 kHz |
|---|---|
| Type | |
| Exposure duration | continuous for 16 min |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 0.11 mT | effective value | measured | - | - |
After melatonin treatment alone, antioxidative enzyme activities were increased and the malondialdehyde level was decreased.
Exposure to extremely low frequency magnetic field alone caused an increase of both superoxide dismutase enzyme activities and malondialdehyde level, but the influence on glutathione peroxidase enzyme activity was negligible.
All enzyme activities in culture medium containing melatonin (all concentrations) were significantly diminished after exposure to extremely low frequency magnetic field compared to cells treated with melatonin alone. Also malondialdehyde levels were significantly decreased after co-exposure to melatonin and extremely low frequency magnetic field.
The authors conclude that the data suggest that extremely low frequency magnetic field attenuates antioxidative actions of melatonin on cellular level.
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